SDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= SDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDC1
  * **<color #00a2e8>Official Name</color>**: syndecan 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6382|6382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18827|P18827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syndecan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast development|
|positive regulation of extracellular exosome assembly|
|regulation of extracellular exosome assembly|
|Sertoli cell development|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|Sertoli cell differentiation|
|myoblast differentiation|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|positive regulation of organelle assembly|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|positive regulation of exocytosis|
|canonical Wnt signaling pathway|
|mesonephros development|
|lysosomal lumen|
|response to cAMP|
|Golgi lumen|
|retinoid metabolic process|
|glycosaminoglycan biosynthetic process|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|response to hydrogen peroxide|
|terpenoid metabolic process|
|odontogenesis|
|kidney epithelium development|
|male gonad development|
|development of primary male sexual characteristics|
|striated muscle cell development|
|response to organophosphorus|
|isoprenoid metabolic process|
|response to glucocorticoid|
|muscle cell development|
|response to calcium ion|
|response to purine-containing compound|
|glycosaminoglycan metabolic process|
|male sex differentiation|
|response to corticosteroid|
|aminoglycan metabolic process|
|protein C-terminus binding|
|carbohydrate derivative catabolic process|
|epithelial cell development|
|response to reactive oxygen species|
|striated muscle cell differentiation|
|gonad development|
|development of primary sexual characteristics|
|regulation of organelle assembly|
|regulation of exocytosis|
|muscle cell differentiation|
|sex differentiation|
|kidney development|
|renal system development|
|response to antibiotic|
|urogenital system development|
|response to steroid hormone|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|response to metal ion|
|leukocyte migration|
|response to oxidative stress|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|positive regulation of secretion|
|muscle structure development|
|wound healing|
|inflammatory response|
|response to toxic substance|
|positive regulation of cellular component biogenesis|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|response to wounding|
|protein-containing complex|
|cell surface|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of organelle organization|
|locomotion|
|defense response|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cell development|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDC1 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>