SDCBP [The Human Chemical-Genetic Interaction Map Project]

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======= SDCBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDCBP
  * **<color #00a2e8>Official Name</color>**: syndecan binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6386|6386]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00560|O00560]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDCBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDCBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-5 receptor complex|
|interleukin-5 receptor binding|
|positive regulation of extracellular exosome assembly|
|regulation of extracellular exosome assembly|
|syndecan binding|
|substrate-dependent cell migration, cell extension|
|negative regulation of receptor internalization|
|cytoskeletal adaptor activity|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|negative regulation of receptor-mediated endocytosis|
|substrate-dependent cell migration|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|frizzled binding|
|negative regulation of endocytosis|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of receptor internalization|
|extracellular vesicle|
|negative regulation of proteasomal protein catabolic process|
|regulation of pathway-restricted SMAD protein phosphorylation|
|adherens junction|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of organelle assembly|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of epithelial to mesenchymal transition|
|negative regulation of cellular protein catabolic process|
|ephrin receptor signaling pathway|
|positive regulation of exocytosis|
|azurophil granule lumen|
|regulation of receptor-mediated endocytosis|
|melanosome|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein N-terminus binding|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|positive regulation of JNK cascade|
|blood microparticle|
|regulation of ubiquitin-dependent protein catabolic process|
|protein targeting to membrane|
|positive regulation of cell growth|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of proteasomal protein catabolic process|
|regulation of JNK cascade|
|regulation of endocytosis|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of organelle assembly|
|regulation of exocytosis|
|membrane raft|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear membrane|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|establishment of protein localization to membrane|
|regulation of cellular response to growth factor stimulus|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|protein targeting|
|cytoskeleton|
|regulation of protein catabolic process|
|positive regulation of secretion by cell|
|focal adhesion|
|regulation of cell growth|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of secretion|
|trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|synaptic signaling|
|protein localization to membrane|
|negative regulation of transport|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|actin filament-based process|
|myeloid leukocyte activation|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|regulation of growth|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDCBP Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>