SDHAF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SDHAF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDHAF2
  * **<color #00a2e8>Official Name</color>**: succinate dehydrogenase complex assembly factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54949|54949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX18|Q9NX18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDHAF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDHAF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613019|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sdh5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-FAD linkage|
|mitochondrial respiratory chain complex II assembly|
|respiratory chain complex II assembly|
|mitochondrial electron transport, succinate to ubiquinone|
|protein-cofactor linkage|
|negative regulation of epithelial to mesenchymal transition|
|tricarboxylic acid cycle|
|aerobic respiration|
|regulation of epithelial to mesenchymal transition|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|negative regulation of canonical Wnt signaling pathway|
|electron transport chain|
|ATP metabolic process|
|negative regulation of Wnt signaling pathway|
|protein dephosphorylation|
|energy derivation by oxidation of organic compounds|
|regulation of canonical Wnt signaling pathway|
|dephosphorylation|
|regulation of Wnt signaling pathway|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|negative regulation of cell differentiation|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of developmental process|
|oxidation-reduction process|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.73|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.76|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.78|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.07|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.11|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:osbp|OSBP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1881
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDHAF2 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>