SDK1 [The Human Chemical-Genetic Interaction Map Project]

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======= SDK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDK1
  * **<color #00a2e8>Official Name</color>**: sidekick cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221935|221935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5N4|Q7Z5N4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607216|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|behavioral response to cocaine|
|retina layer formation|
|retina morphogenesis in camera-type eye|
|response to cocaine|
|neural retina development|
|regulation of dendritic spine development|
|response to anesthetic|
|synapse assembly|
|response to alkaloid|
|camera-type eye morphogenesis|
|cell-cell junction organization|
|retina development in camera-type eye|
|adult behavior|
|eye morphogenesis|
|regulation of dendrite development|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|response to ammonium ion|
|cell junction organization|
|sensory organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse|
|synapse organization|
|response to xenobiotic stimulus|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|regulation of neuron projection development|
|cell-cell adhesion|
|sensory organ development|
|cell junction|
|behavior|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|anatomical structure formation involved in morphogenesis|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|response to organonitrogen compound|
|response to drug|
|identical protein binding|
|response to nitrogen compound|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.73|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.7|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.81|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.93|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.98|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.17|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.2|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.49|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.13|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.42|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|4.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12281
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDK1 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>