SEC22B [The Human Chemical-Genetic Interaction Map Project]

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======= SEC22B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC22B
  * **<color #00a2e8>Official Name</color>**: SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9554|9554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75396|O75396]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC22B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC22B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604029|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaptobrevin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|
|vesicle fusion with Golgi apparatus|
|negative regulation of autophagosome assembly|
|SNAP receptor activity|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|negative regulation of organelle assembly|
|regulation of vacuole organization|
|SNARE complex|
|ER to Golgi transport vesicle membrane|
|syntaxin binding|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|vesicle fusion|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endoplasmic reticulum-Golgi intermediate compartment|
|Golgi vesicle budding|
|organelle membrane fusion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|negative regulation of autophagy|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle targeting|
|transport vesicle|
|vesicle budding from membrane|
|organelle fusion|
|antigen processing and presentation of peptide antigen via MHC class I|
|melanosome|
|synaptic vesicle|
|membrane fusion|
|regulation of macroautophagy|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|positive regulation of protein catabolic process|
|antigen processing and presentation|
|regulation of organelle assembly|
|negative regulation of cellular catabolic process|
|vesicle organization|
|negative regulation of catabolic process|
|regulation of autophagy|
|establishment of organelle localization|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|organelle localization|
|Golgi membrane|
|negative regulation of cellular component organization|
|regulation of cellular catabolic process|
|membrane organization|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|endoplasmic reticulum|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.98|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC22B Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>