SEC23B [The Human Chemical-Genetic Interaction Map Project]

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======= SEC23B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC23B
  * **<color #00a2e8>Official Name</color>**: SEC23 homolog B, COPII coat complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10483|10483]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15437|Q15437]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC23B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC23B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. {ECO:0000250|UniProtKB:Q15436}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec23 helical|
|zf-Sec23 Sec24|
|Sec23 trunk|
|Gelsolin|
|Sec23 BS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPII-coated vesicle cargo loading|
|COPII vesicle coat|
|vesicle cargo loading|
|endoplasmic reticulum exit site|
|COPII-coated vesicle budding|
|endomembrane system|
|Golgi vesicle budding|
|localization within membrane|
|vesicle budding from membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|GTPase activator activity|
|vesicle organization|
|Golgi vesicle transport|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|Golgi membrane|
|perinuclear region of cytoplasm|
|positive regulation of hydrolase activity|
|zinc ion binding|
|membrane organization|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.39|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.24|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.11|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.05|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.01|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.97|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.95|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.94|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.92|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.82|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.81|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.8|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.87|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.05|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.09|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.11|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.12|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.15|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.43|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.53|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|4.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec31a|SEC31A]]|0.582|
|[[:human genes:s:sar1a|SAR1A]]|0.561|
|[[:human genes:s:sec24c|SEC24C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC23B Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>