SEC24B [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SEC24B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC24B
  * **<color #00a2e8>Official Name</color>**: SEC24 homolog B, COPII coat complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10427|10427]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95487|O95487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC24B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC24B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607184|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec23 BS|
|Gelsolin|
|Sec23 trunk|
|zf-Sec23 Sec24|
|Sec23 helical|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cargo loading into COPII-coated vesicle|
|cochlear nucleus development|
|pulmonary artery morphogenesis|
|lung lobe morphogenesis|
|lung lobe development|
|coronary artery morphogenesis|
|pons development|
|auditory receptor cell stereocilium organization|
|auditory receptor cell morphogenesis|
|COPII-coated vesicle cargo loading|
|COPII vesicle coat|
|regulation of establishment of planar polarity involved in neural tube closure|
|coronary vasculature morphogenesis|
|regulation of ER to Golgi vesicle-mediated transport|
|auditory receptor cell development|
|regulation of epithelial tube formation|
|inner ear auditory receptor cell differentiation|
|vesicle cargo loading|
|inner ear receptor cell stereocilium organization|
|aorta morphogenesis|
|hair cell differentiation|
|inner ear receptor cell development|
|lung morphogenesis|
|neuroepithelial cell differentiation|
|coronary vasculature development|
|columnar/cuboidal epithelial cell development|
|aorta development|
|inner ear receptor cell differentiation|
|ER to Golgi transport vesicle membrane|
|mechanoreceptor differentiation|
|artery morphogenesis|
|neural nucleus development|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|outflow tract morphogenesis|
|Golgi vesicle budding|
|localization within membrane|
|artery development|
|vesicle targeting|
|neural tube closure|
|tube closure|
|columnar/cuboidal epithelial cell differentiation|
|vesicle budding from membrane|
|inner ear morphogenesis|
|antigen processing and presentation of peptide antigen via MHC class I|
|primary neural tube formation|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|neural tube formation|
|regulation of establishment of planar polarity|
|metencephalon development|
|ear morphogenesis|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|hindbrain development|
|neural tube development|
|lung development|
|respiratory tube development|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|epithelial cell development|
|inner ear development|
|respiratory system development|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|ear development|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|embryonic organ morphogenesis|
|vesicle organization|
|epithelial tube morphogenesis|
|epidermal cell differentiation|
|regulation of intracellular transport|
|establishment of organelle localization|
|Golgi vesicle transport|
|blood vessel morphogenesis|
|epidermis development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|organelle localization|
|Golgi membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|zinc ion binding|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|intracellular protein transport|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.4|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.26|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.75|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.76|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.78|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.88|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.9|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.9|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.91|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.93|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.01|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.18|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18179
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC24B Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>