SEL1L [The Human Chemical-Genetic Interaction Map Project]

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======= SEL1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEL1L
  * **<color #00a2e8>Official Name</color>**: SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6400|6400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBV2|Q9UBV2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEL1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEL1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602329|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn2|
|Sel1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Hrd1p ubiquitin ligase complex|
|Hrd1p ubiquitin ligase ERAD-L complex|
|Derlin-1 retrotranslocation complex|
|endoplasmic reticulum mannose trimming|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|protein alpha-1,2-demannosylation|
|protein demannosylation|
|endoplasmic reticulum quality control compartment|
|protein exit from endoplasmic reticulum|
|protein deglycosylation|
|ubiquitin-dependent ERAD pathway|
|triglyceride metabolic process|
|ERAD pathway|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|Notch signaling pathway|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|protein stabilization|
|ubiquitin-protein transferase activity|
|response to endoplasmic reticulum stress|
|regulation of protein stability|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|glycerolipid metabolic process|
|glycoprotein metabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|secretion|
|lipid metabolic process|
|proteolysis|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.8|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.76|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.77|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.77|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.78|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.84|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.89|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.92|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.94|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.94|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.13|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.485|
|[[:human genes:d:ddtl|DDTL]]|0.479|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.476|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.468|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.468|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.454|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.453|
|[[:human genes:p:psmd3|PSMD3]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:s:sec13|SEC13]]|0.448|
|[[:human genes:a:atp13a1|ATP13A1]]|0.444|
|[[:human genes:d:dock6|DOCK6]]|0.437|
|[[:human genes:s:syt9|SYT9]]|0.437|
|[[:human genes:w:wdr43|WDR43]]|0.433|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.433|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.43|
|[[:human genes:s:smg7|SMG7]]|0.429|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.428|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.427|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.427|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.426|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.426|
|[[:human genes:m:med17|MED17]]|0.425|
|[[:human genes:p:polr2j3|POLR2J3]]|0.423|
|[[:human genes:c:ccdc94|CCDC94]]|0.42|
|[[:human genes:s:slc4a1|SLC4A1]]|0.419|
|[[:human genes:t:tfip11|TFIP11]]|0.419|
|[[:human genes:r:rrn3|RRN3]]|0.418|
|[[:human genes:c:cope|COPE]]|0.414|
|[[:human genes:p:psmd1|PSMD1]]|0.414|
|[[:human genes:r:rfxank|RFXANK]]|0.413|
|[[:human genes:c:casc3|CASC3]]|0.412|
|[[:human genes:c:cdc45|CDC45]]|0.412|
|[[:human genes:r:rps14|RPS14]]|0.41|
|[[:human genes:a:akirin2|AKIRIN2]]|0.409|
|[[:human genes:t:tceb3c|TCEB3C]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.407|
|[[:human genes:s:smg1|SMG1]]|0.403|
|[[:human genes:n:ndc1|NDC1]]|0.403|
|[[:human genes:f:fcn2|FCN2]]|0.401|
|[[:human genes:m:mt1e|MT1E]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEL1L Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>