SELT [The Human Chemical-Genetic Interaction Map Project]

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======= SELT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SELENOT
  * **<color #00a2e8>Official Name</color>**: selenoprotein T
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51714|51714]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62341|P62341]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SELT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SELT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:P62342, ECO:0000250|UniProtKB:Q1H5H1, ECO:0000269|PubMed:26866473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rdx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translational readthrough|
|thioredoxin-disulfide reductase activity|
|selenocysteine incorporation|
|insulin secretion involved in cellular response to glucose stimulus|
|selenium binding|
|positive regulation of growth hormone secretion|
|regulation of growth hormone secretion|
|insulin secretion|
|peptide hormone secretion|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|pancreas development|
|hormone secretion|
|cellular response to monosaccharide stimulus|
|cell redox homeostasis|
|cellular response to carbohydrate stimulus|
|hormone transport|
|cellular glucose homeostasis|
|cellular oxidant detoxification|
|positive regulation of peptide hormone secretion|
|cellular detoxification|
|translational elongation|
|detoxification|
|positive regulation of hormone secretion|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of peptide hormone secretion|
|cellular response to toxic substance|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of cytosolic calcium ion concentration|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|peptide biosynthetic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to toxic substance|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|cellular amide metabolic process|
|regulation of secretion|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|positive regulation of transport|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17669
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SELT Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>