SEMA4D [The Human Chemical-Genetic Interaction Map Project]

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======= SEMA4D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA4D
  * **<color #00a2e8>Official Name</color>**: semaphorin 4D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10507|10507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92854|Q92854]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA4D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA4D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PSI|
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inhibitory synapse assembly|
|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|
|regulation of inhibitory synapse assembly|
|negative regulation of alkaline phosphatase activity|
|regulation of alkaline phosphatase activity|
|leukocyte aggregation|
|positive regulation of collateral sprouting|
|bone trabecula morphogenesis|
|ossification involved in bone maturation|
|bone maturation|
|neuropilin binding|
|regulation of collateral sprouting|
|animal organ maturation|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|negative regulation of osteoblast differentiation|
|regulation of axon guidance|
|trabecula morphogenesis|
|negative chemotaxis|
|leukocyte cell-cell adhesion|
|negative regulation of peptidyl-tyrosine phosphorylation|
|neural crest cell migration|
|negative regulation of chemotaxis|
|positive regulation of synapse assembly|
|negative regulation of axonogenesis|
|negative regulation of ossification|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|positive regulation of axonogenesis|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|neural crest cell differentiation|
|regulation of dendrite morphogenesis|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of synapse assembly|
|negative regulation of developmental growth|
|negative regulation of phosphatase activity|
|regulation of extent of cell growth|
|negative regulation of dephosphorylation|
|regulation of osteoblast differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|anatomical structure maturation|
|transmembrane signaling receptor activity|
|regulation of dendrite development|
|regulation of cell shape|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|regulation of phosphatase activity|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of ossification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|bone development|
|signaling receptor activity|
|regulation of dephosphorylation|
|regulation of chemotaxis|
|regulation of synapse organization|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|developmental maturation|
|negative regulation of growth|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|ossification|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|signaling receptor binding|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of cell growth|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cell-cell adhesion|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA4D Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>