SEPT7 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SEPT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEPTIN7
  * **<color #00a2e8>Official Name</color>**: septin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=989|989]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16181|Q16181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEPT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEPT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603151|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Septin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of embryonic cell shape|
|sperm annulus|
|positive regulation of non-motile cilium assembly|
|regulation of non-motile cilium assembly|
|septin complex|
|septin ring|
|positive regulation of cilium assembly|
|non-motile cilium|
|cleavage furrow|
|stress fiber|
|positive regulation of organelle assembly|
|regulation of cilium assembly|
|condensed chromosome kinetochore|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of plasma membrane bounded cell projection assembly|
|negative regulation of G1/S transition of mitotic cell cycle|
|axoneme|
|negative regulation of cell cycle G1/S phase transition|
|protein heterooligomerization|
|spindle|
|regulation of embryonic development|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell shape|
|microtubule cytoskeleton|
|midbody|
|regulation of cell cycle G1/S phase transition|
|structural molecule activity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|negative regulation of mitotic cell cycle phase transition|
|regulation of organelle assembly|
|negative regulation of cell cycle phase transition|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of mitotic cell cycle|
|negative regulation of cellular component movement|
|cadherin binding|
|apical plasma membrane|
|negative regulation of locomotion|
|negative regulation of cell cycle process|
|GTPase activity|
|cilium assembly|
|cilium organization|
|positive regulation of cell projection organization|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|regulation of cell morphogenesis|
|cell division|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|regulation of cell cycle process|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cell cycle process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEPT7 Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>