SERF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SERF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERF2
  * **<color #00a2e8>Official Name</color>**: small EDRK-rich factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10169|10169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P84101|P84101]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|4F5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.81|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.71|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.73|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.74|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.75|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.83|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.84|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.87|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.95|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.99|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.19|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.19|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.28|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.32|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.33|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.34|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.42|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.44|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.44|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.64|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.73|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.83|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.85|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.86|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.95|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.691|
|[[:human genes:v:vdac2|VDAC2]]|0.672|
|[[:human genes:m:march5|MARCH5]]|0.663|
|[[:human genes:u:ubqln1|UBQLN1]]|0.66|
|[[:human genes:c:casp9|CASP9]]|0.629|
|[[:human genes:a:apaf1|APAF1]]|0.602|
|[[:human genes:d:dohh|DOHH]]|0.594|
|[[:human genes:f:faf2|FAF2]]|0.589|
|[[:human genes:c:cycs|CYCS]]|0.586|
|[[:human genes:p:plaa|PLAA]]|0.571|
|[[:human genes:d:diablo|DIABLO]]|0.542|
|[[:human genes:r:rptor|RPTOR]]|0.532|
|[[:human genes:r:romo1|ROMO1]]|0.529|
|[[:human genes:m:mlst8|MLST8]]|0.521|
|[[:human genes:h:hccs|HCCS]]|0.52|
|[[:human genes:m:mtor|MTOR]]|0.513|
|[[:human genes:f:fbxo11|FBXO11]]|0.513|
|[[:human genes:m:mfn1|MFN1]]|0.51|
|[[:human genes:m:metap2|METAP2]]|0.506|
|[[:human genes:w:wdr24|WDR24]]|0.503|
|[[:human genes:g:gabpa|GABPA]]|0.502|
|[[:human genes:a:atad1|ATAD1]]|0.499|
|[[:human genes:t:triap1|TRIAP1]]|0.486|
|[[:human genes:b:bap1|BAP1]]|0.485|
|[[:human genes:t:thg1l|THG1L]]|0.48|
|[[:human genes:e:eny2|ENY2]]|0.472|
|[[:human genes:k:kdsr|KDSR]]|0.472|
|[[:human genes:g:gfpt1|GFPT1]]|0.471|
|[[:human genes:o:opa1|OPA1]]|0.451|
|[[:human genes:c:crls1|CRLS1]]|0.451|
|[[:human genes:s:srrd|SRRD]]|0.449|
|[[:human genes:n:nsd1|NSD1]]|0.447|
|[[:human genes:u:uap1|UAP1]]|0.441|
|[[:human genes:s:stau1|STAU1]]|0.44|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.439|
|[[:human genes:v:vhl|VHL]]|0.433|
|[[:human genes:m:meaf6|MEAF6]]|0.423|
|[[:human genes:w:wdr59|WDR59]]|0.422|
|[[:human genes:d:ddhd2|DDHD2]]|0.422|
|[[:human genes:t:trim28|TRIM28]]|0.422|
|[[:human genes:t:thoc6|THOC6]]|0.42|
|[[:human genes:p:pmm2|PMM2]]|0.418|
|[[:human genes:m:mios|MIOS]]|0.416|
|[[:human genes:z:zzz3|ZZZ3]]|0.415|
|[[:human genes:a:atp5j|ATP5J]]|0.413|
|[[:human genes:b:bptf|BPTF]]|0.412|
|[[:human genes:d:dpagt1|DPAGT1]]|0.411|
|[[:human genes:a:atp5d|ATP5D]]|0.411|
|[[:human genes:u:ube2g2|UBE2G2]]|0.41|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.41|
|[[:human genes:i:id3|ID3]]|0.409|
|[[:human genes:a:atp5b|ATP5B]]|0.407|
|[[:human genes:k:kctd5|KCTD5]]|0.406|
|[[:human genes:a:atp5i|ATP5I]]|0.406|
|[[:human genes:p:ppa2|PPA2]]|0.406|
|[[:human genes:r:rpe|RPE]]|0.405|
|[[:human genes:f:fech|FECH]]|0.404|
|[[:human genes:a:atp5h|ATP5H]]|0.403|
|[[:human genes:a:atp5l|ATP5L]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2595
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERF2 Expression in NALM6 Cells: 7.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>