SERPINB3 [The Human Chemical-Genetic Interaction Map Project]

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======= SERPINB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINB3
  * **<color #00a2e8>Official Name</color>**: serpin family B member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6317|6317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29508|P29508]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600517|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|paracrine signaling|
|autocrine signaling|
|negative regulation of JUN kinase activity|
|cysteine-type endopeptidase inhibitor activity|
|negative regulation of JNK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of MAP kinase activity|
|virus receptor activity|
|regulation of epithelial to mesenchymal transition|
|regulation of JUN kinase activity|
|azurophil granule lumen|
|viral entry into host cell|
|serine-type endopeptidase inhibitor activity|
|entry into host|
|entry into host cell|
|protease binding|
|negative regulation of protein serine/threonine kinase activity|
|vesicle|
|interaction with host|
|negative regulation of MAPK cascade|
|positive regulation of endopeptidase activity|
|regulation of JNK cascade|
|positive regulation of peptidase activity|
|viral life cycle|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of endopeptidase activity|
|negative regulation of kinase activity|
|cytoplasmic vesicle|
|negative regulation of peptidase activity|
|negative regulation of transferase activity|
|regulation of MAP kinase activity|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|viral process|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|symbiotic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINB3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>