SERPINE1 [The Human Chemical-Genetic Interaction Map Project]

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======= SERPINE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINE1
  * **<color #00a2e8>Official Name</color>**: serpin family E member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5054|5054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05121|P05121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). {ECO:0000250|UniProtKB:P22777, ECO:0000269|PubMed:15001579, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:16862142, ECO:0000269|PubMed:17912461, ECO:0000269|PubMed:18386027, ECO:0000269|PubMed:25808697, ECO:0000269|PubMed:27046084, ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9168821, ECO:0000269|PubMed:9175705, ECO:0000269|PubMed:9207454}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of odontoblast differentiation|
|positive regulation of leukotriene production involved in inflammatory response|
|negative regulation of vascular wound healing|
|regulation of leukotriene production involved in inflammatory response|
|negative regulation of smooth muscle cell-matrix adhesion|
|chronological cell aging|
|positive regulation of neuroepithelial cell differentiation|
|regulation of odontoblast differentiation|
|regulation of smooth muscle cell-matrix adhesion|
|regulation of vascular wound healing|
|negative regulation of plasminogen activation|
|dentinogenesis|
|negative regulation of fibrinolysis|
|negative regulation of cell adhesion mediated by integrin|
|replicative senescence|
|regulation of fibrinolysis|
|regulation of plasminogen activation|
|positive regulation of monocyte chemotaxis|
|fibrinolysis|
|negative regulation of smooth muscle cell migration|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of protein maturation|
|negative regulation of protein processing|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of cell-matrix adhesion|
|negative regulation of epithelial cell apoptotic process|
|regulation of mononuclear cell migration|
|regulation of cell adhesion mediated by integrin|
|positive regulation of interleukin-8 production|
|regulation of endothelial cell apoptotic process|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of receptor-mediated endocytosis|
|positive regulation of wound healing|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of epithelial cell differentiation|
|regulation of smooth muscle cell migration|
|negative regulation of cell-substrate adhesion|
|cell aging|
|positive regulation of response to wounding|
|regulation of protein processing|
|platelet alpha granule lumen|
|regulation of protein maturation|
|regulation of interleukin-8 production|
|negative regulation of wound healing|
|regulation of epithelial cell apoptotic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|odontogenesis of dentin-containing tooth|
|defense response to Gram-negative bacterium|
|negative regulation of response to wounding|
|positive regulation of leukocyte chemotaxis|
|serine-type endopeptidase inhibitor activity|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|negative regulation of extrinsic apoptotic signaling pathway|
|protease binding|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of leukocyte chemotaxis|
|regulation of cell-matrix adhesion|
|negative regulation of vasculature development|
|odontogenesis|
|platelet degranulation|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of wound healing|
|positive regulation of inflammatory response|
|regulation of epithelial cell differentiation|
|circadian rhythm|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|regulation of signaling receptor activity|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|regulation of endocytosis|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|negative regulation of apoptotic signaling pathway|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|rhythmic process|
|aging|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|defense response to bacterium|
|signaling receptor binding|
|regulation of inflammatory response|
|extracellular matrix organization|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|extracellular structure organization|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|positive regulation of defense response|
|blood vessel development|
|regulation of body fluid levels|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of defense response|
|negative regulation of catalytic activity|
|exocytosis|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINE1 Expression in NALM6 Cells: 0.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>