SERPINF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SERPINF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINF2
  * **<color #00a2e8>Official Name</color>**: serpin family F member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5345|5345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08697|P08697]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of blood vessel diameter by renin-angiotensin|
|renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure|
|negative regulation of plasminogen activation|
|fibrinogen complex|
|negative regulation of fibrinolysis|
|positive regulation of cell-cell adhesion mediated by cadherin|
|regulation of plasminogen activation|
|regulation of fibrinolysis|
|regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of transforming growth factor beta production|
|fibrinolysis|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|renal system process involved in regulation of systemic arterial blood pressure|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|endopeptidase inhibitor activity|
|regulation of collagen biosynthetic process|
|regulation of transforming growth factor beta production|
|regulation of systemic arterial blood pressure by hormone|
|acute-phase response|
|regulation of collagen metabolic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|collagen fibril organization|
|endocrine process|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|positive regulation of stress fiber assembly|
|negative regulation of coagulation|
|positive regulation of wound healing|
|positive regulation of actin filament bundle assembly|
|positive regulation of response to wounding|
|regulation of protein processing|
|platelet alpha granule lumen|
|regulation of protein maturation|
|acute inflammatory response|
|negative regulation of wound healing|
|regulation of stress fiber assembly|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|positive regulation of smooth muscle cell proliferation|
|negative regulation of response to wounding|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of systemic arterial blood pressure|
|serine-type endopeptidase inhibitor activity|
|protease binding|
|renal system process|
|platelet degranulation|
|regulation of smooth muscle cell proliferation|
|regulation of wound healing|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|positive regulation of JNK cascade|
|regulation of tube size|
|blood microparticle|
|regulation of response to wounding|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|vascular process in circulatory system|
|regulation of blood pressure|
|regulation of JNK cascade|
|positive regulation of supramolecular fiber organization|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of cytoskeleton organization|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of endopeptidase activity|
|positive regulation of cell-cell adhesion|
|negative regulation of peptidase activity|
|regulation of actin filament organization|
|regulation of ERK1 and ERK2 cascade|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|extracellular structure organization|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|blood vessel development|
|regulation of body fluid levels|
|inflammatory response|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of organelle organization|
|tube morphogenesis|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|exocytosis|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINF2 Expression in NALM6 Cells: -0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>