SESN2 [The Human Chemical-Genetic Interaction Map Project]

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======= SESN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SESN2
  * **<color #00a2e8>Official Name</color>**: sestrin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83667|83667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58004|P58004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SESN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SESN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PA26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of translation in response to endoplasmic reticulum stress|
|sulfiredoxin activity|
|positive regulation of lipophagy|
|regulation of lipophagy|
|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|oxidoreductase activity, acting on peroxide as acceptor|
|negative regulation of translation in response to stress|
|regulation of translation in response to endoplasmic reticulum stress|
|leucine binding|
|Atg1/ULK1 kinase complex|
|glucose import|
|mitochondrial DNA metabolic process|
|cellular response to leucine starvation|
|cellular response to leucine|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|GDP-dissociation inhibitor activity|
|TORC2 complex|
|response to leucine|
|GATOR2 complex|
|nucleotide-activated protein kinase complex|
|regulation of translation in response to stress|
|regulation of cAMP-dependent protein kinase activity|
|negative regulation of TORC1 signaling|
|mitochondrial genome maintenance|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|glucose transmembrane transport|
|regulation of response to reactive oxygen species|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|protein kinase B signaling|
|regulation of TORC1 signaling|
|carbohydrate transmembrane transport|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|regulation of gluconeogenesis|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|fatty acid beta-oxidation|
|positive regulation of macroautophagy|
|cellular response to amino acid stimulus|
|positive regulation of protein localization to nucleus|
|carbohydrate transport|
|fatty acid oxidation|
|lipid oxidation|
|DNA damage response, signal transduction by p53 class mediator|
|regulation of response to oxidative stress|
|cellular oxidant detoxification|
|fatty acid catabolic process|
|regulation of carbohydrate biosynthetic process|
|cellular detoxification|
|regulation of TOR signaling|
|signal transduction in response to DNA damage|
|reactive oxygen species metabolic process|
|regulation of glucose metabolic process|
|response to amino acid|
|regulation of protein localization to nucleus|
|monocarboxylic acid catabolic process|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|signal transduction by p53 class mediator|
|positive regulation of autophagy|
|regulation of DNA-templated transcription in response to stress|
|detoxification|
|negative regulation of translation|
|lipid homeostasis|
|response to glucose|
|regulation of cellular carbohydrate metabolic process|
|response to hexose|
|negative regulation of cellular amide metabolic process|
|response to monosaccharide|
|cellular response to starvation|
|response to carbohydrate|
|regulation of macroautophagy|
|negative regulation of cell growth|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|cellular lipid catabolic process|
|lipid modification|
|regulation of carbohydrate metabolic process|
|cellular response to acid chemical|
|cellular response to toxic substance|
|response to insulin|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|negative regulation of growth|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|regulation of translation|
|positive regulation of cellular catabolic process|
|response to oxidative stress|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|small molecule catabolic process|
|mitochondrion organization|
|response to peptide|
|response to nutrient levels|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|posttranscriptional regulation of gene expression|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of cellular protein localization|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cellular localization|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.99|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.66|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.38|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.17|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.04|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.97|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.74|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nprl3|NPRL3]]|0.656|
|[[:human genes:s:szt2|SZT2]]|0.653|
|[[:human genes:i:itfg2|ITFG2]]|0.611|
|[[:human genes:k:kptn|KPTN]]|0.606|
|[[:human genes:d:depdc5|DEPDC5]]|0.598|
|[[:human genes:n:nprl2|NPRL2]]|0.591|
|[[:human genes:c:c12orf66|C12orf66]]|0.564|
|[[:human genes:t:tsc2|TSC2]]|0.463|
|[[:human genes:t:tsc1|TSC1]]|0.438|
|[[:human genes:c:ccdc130|CCDC130]]|0.422|
|[[:human genes:p:pds5b|PDS5B]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18603
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SESN2 Expression in NALM6 Cells: 4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>