SETD1A [The Human Chemical-Genetic Interaction Map Project]

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======= SETD1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SETD1A
  * **<color #00a2e8>Official Name</color>**: SET domain containing 1A, histone lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9739|9739]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15047|O15047]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SETD1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SETD1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269|PubMed:12670868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|N-SET|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Set1C/COMPASS complex|
|histone methyltransferase activity (H3-K4 specific)|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|regulation of megakaryocyte differentiation|
|histone lysine methylation|
|regulation of hematopoietic stem cell differentiation|
|beta-catenin binding|
|regulation of hematopoietic progenitor cell differentiation|
|peptidyl-lysine methylation|
|histone methylation|
|regulation of stem cell differentiation|
|protein methylation|
|protein alkylation|
|regulation of chromatin organization|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|transcription factor binding|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|regulation of hemopoiesis|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of organelle organization|
|RNA binding|
|regulation of immune system process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.12|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.75|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.8|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.88|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.51|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.581|
|[[:human genes:z:znf148|ZNF148]]|0.477|
|[[:human genes:i:iscu|ISCU]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.449|
|[[:human genes:b:bod1l1|BOD1L1]]|0.445|
|[[:human genes:z:zfand5|ZFAND5]]|0.439|
|[[:human genes:p:paf1|PAF1]]|0.437|
|[[:human genes:p:psma6|PSMA6]]|0.436|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.435|
|[[:human genes:d:dido1|DIDO1]]|0.434|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.414|
|[[:human genes:p:ppie|PPIE]]|0.413|
|[[:human genes:r:rnf113a|RNF113A]]|0.413|
|[[:human genes:c:cdk12|CDK12]]|0.41|
|[[:human genes:n:nsf|NSF]]|0.41|
|[[:human genes:d:dnm2|DNM2]]|0.409|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.409|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.408|
|[[:human genes:p:psmb4|PSMB4]]|0.406|
|[[:human genes:a:akap1|AKAP1]]|0.405|
|[[:human genes:t:tceb3c|TCEB3C]]|0.405|
|[[:human genes:r:rnpc3|RNPC3]]|0.403|
|[[:human genes:s:sf3a1|SF3A1]]|0.402|
|[[:human genes:l:loxl1|LOXL1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 338/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|11/28|
|bone|14/25|
|breast|19/33|
|central nervous system|28/56|
|cervix|3/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|9/21|
|liver|16/20|
|lung|27/75|
|lymphocyte|7/14|
|ovary|14/26|
|pancreas|9/24|
|peripheral nervous system|5/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SETD1A Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>