SETD1B [The Human Chemical-Genetic Interaction Map Project]

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======= SETD1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SETD1B
  * **<color #00a2e8>Official Name</color>**: SET domain containing 1B, histone lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23067|23067]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPS6|Q9UPS6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SETD1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SETD1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|N-SET|
|RRM 1|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Set1C/COMPASS complex|
|histone methyltransferase activity (H3-K4 specific)|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|chromosome|
|protein methylation|
|protein alkylation|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.23|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.06|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.88|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.86|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.77|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.74|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.89|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.06|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.38|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.61|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.83|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:erg|ERG]]|0.435|
|[[:human genes:r:runx1|RUNX1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SETD1B Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>