SGIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SGIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGIP1
  * **<color #00a2e8>Official Name</color>**: SH3GL interacting endocytic adaptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84251|84251]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQI5|Q9BQI5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|muHD|
|Adap comp sub|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of feeding behavior|
|AP-2 adaptor complex|
|plasma membrane tubulation|
|clathrin coat assembly|
|clathrin-dependent endocytosis|
|response to dietary excess|
|positive regulation of behavior|
|regulation of feeding behavior|
|energy homeostasis|
|positive regulation of receptor-mediated endocytosis|
|tubulin binding|
|clathrin-coated pit|
|clathrin-coated vesicle|
|regulation of behavior|
|cytoskeletal protein binding|
|plasma membrane organization|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|phospholipid binding|
|SH3 domain binding|
|regulation of endocytosis|
|receptor-mediated endocytosis|
|microtubule binding|
|multicellular organismal homeostasis|
|cytoskeleton|
|endomembrane system organization|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of vesicle-mediated transport|
|endocytosis|
|import into cell|
|cellular protein-containing complex assembly|
|membrane organization|
|positive regulation of transport|
|positive regulation of cellular component organization|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.99|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.75|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.7|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.73|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.86|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGIP1 Expression in NALM6 Cells: -1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>