SGOL1 [The Human Chemical-Genetic Interaction Map Project]

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======= SGOL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGO1
  * **<color #00a2e8>Official Name</color>**: shugoshin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151648|151648]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5FBB7|Q5FBB7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGOL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGOL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Shugoshin C|
|Shugoshin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic sister chromatid cohesion, centromeric|
|centromeric sister chromatid cohesion|
|condensed chromosome, centromeric region|
|centriole-centriole cohesion|
|condensed nuclear chromosome, centromeric region|
|mitotic sister chromatid cohesion|
|attachment of spindle microtubules to kinetochore|
|sister chromatid cohesion|
|chromosome, centromeric region|
|centrosome cycle|
|kinetochore|
|condensed chromosome kinetochore|
|meiotic chromosome segregation|
|microtubule organizing center organization|
|kinase binding|
|mitotic sister chromatid segregation|
|spindle pole|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.4|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.36|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.02|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.98|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.75|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.85|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.24|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.27|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.35|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.05|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|4.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hspd1|HSPD1]]|0.448|
|[[:human genes:r:rpp21|RPP21]]|0.445|
|[[:human genes:a:anapc15|ANAPC15]]|0.424|
|[[:human genes:s:srpk1|SRPK1]]|0.422|
|[[:human genes:a:anapc13|ANAPC13]]|0.41|
|[[:human genes:a:aspm|ASPM]]|0.409|
|[[:human genes:d:ddx55|DDX55]]|0.407|
|[[:human genes:a:alg1|ALG1]]|0.404|
|[[:human genes:f:fnta|FNTA]]|0.404|
|[[:human genes:u:utp23|UTP23]]|0.403|
|[[:human genes:a:adsl|ADSL]]|0.401|
|[[:human genes:t:thg1l|THG1L]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 354/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|12/28|
|bone|12/26|
|breast|15/33|
|central nervous system|22/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|13/21|
|liver|12/20|
|lung|40/75|
|lymphocyte|9/16|
|ovary|15/26|
|pancreas|16/24|
|peripheral nervous system|9/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16948
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGOL1 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>