SGOL2 [The Human Chemical-Genetic Interaction Map Project]

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======= SGOL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGO2
  * **<color #00a2e8>Official Name</color>**: shugoshin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151246|151246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q562F6|Q562F6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGOL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGOL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Shugoshin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic cohesin complex|
|meiotic sister chromatid cohesion, centromeric|
|meiotic sister chromatid segregation|
|centromeric sister chromatid cohesion|
|meiotic sister chromatid cohesion|
|meiosis II|
|meiosis II cell cycle process|
|sister chromatid cohesion|
|chromosome, centromeric region|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|condensed chromosome kinetochore|
|sister chromatid segregation|
|meiotic nuclear division|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|cell division|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-4.42|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.53|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.22|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.19|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.13|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12626
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGOL2 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>