SGTA [The Human Chemical-Genetic Interaction Map Project]

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======= SGTA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGTA
  * **<color #00a2e8>Official Name</color>**: small glutamine rich tetratricopeptide repeat containing alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6449|6449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43765|O43765]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGTA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGTA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603419|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|TPR 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRC complex|
|positive regulation of chaperone-mediated protein folding|
|positive regulation of protein folding|
|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of chaperone-mediated protein folding|
|extrinsic component of synaptic vesicle membrane|
|BAT3 complex binding|
|tail-anchored membrane protein insertion into ER membrane|
|protein insertion into ER membrane|
|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of protein folding|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|negative regulation of ERAD pathway|
|positive regulation of ERAD pathway|
|regulation of ERAD pathway|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|protein insertion into membrane|
|positive regulation of response to endoplasmic reticulum stress|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of ubiquitin-dependent protein catabolic process|
|endoplasmic reticulum organization|
|protein self-association|
|negative regulation of proteasomal protein catabolic process|
|chaperone-mediated protein folding|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|protein localization to endoplasmic reticulum|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|protein targeting to membrane|
|regulation of proteasomal protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|protein folding|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|establishment of protein localization to membrane|
|negative regulation of catabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|protein targeting|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|endomembrane system organization|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|protein localization to membrane|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|viral process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|proteolysis|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.79|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.94|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.492|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGTA Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>