SH2B3 [The Human Chemical-Genetic Interaction Map Project]

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======= SH2B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH2B3
  * **<color #00a2e8>Official Name</color>**: SH2B adaptor protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10019|10019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQQ2|Q9UQQ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH2B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH2B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605093|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|Phe ZIP|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Kit signaling pathway|
|monocyte homeostasis|
|negative regulation of Kit signaling pathway|
|stem cell factor receptor binding|
|thrombopoietin-mediated signaling pathway|
|response to interleukin-3|
|cellular response to interleukin-3|
|negative regulation of chemokine-mediated signaling pathway|
|regulation of chemokine-mediated signaling pathway|
|neutrophil homeostasis|
|negative regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of platelet aggregation|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|negative regulation of homotypic cell-cell adhesion|
|megakaryocyte development|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|negative regulation of receptor signaling pathway via JAK-STAT|
|embryonic hemopoiesis|
|negative regulation of receptor signaling pathway via STAT|
|megakaryocyte differentiation|
|bone cell development|
|regulation of homotypic cell-cell adhesion|
|protein tyrosine kinase binding|
|regulation of platelet activation|
|erythrocyte development|
|negative regulation of protein kinase B signaling|
|negative regulation of blood coagulation|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|SH3/SH2 adaptor activity|
|myeloid cell development|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|leukocyte homeostasis|
|negative regulation of wound healing|
|negative regulation of MAP kinase activity|
|regulation of blood coagulation|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of hemostasis|
|erythrocyte differentiation|
|chemokine-mediated signaling pathway|
|regulation of coagulation|
|negative regulation of response to wounding|
|erythrocyte homeostasis|
|response to chemokine|
|cellular response to chemokine|
|myeloid cell homeostasis|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of protein serine/threonine kinase activity|
|regulation of receptor signaling pathway via STAT|
|regulation of wound healing|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to wounding|
|negative regulation of MAPK cascade|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|negative regulation of cell activation|
|homeostasis of number of cells|
|bone development|
|regulation of protein kinase B signaling|
|myeloid cell differentiation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|embryonic organ development|
|negative regulation of phosphorylation|
|wound healing|
|skeletal system development|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|embryo development|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8544
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH2B3 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>