SH3PXD2B [The Human Chemical-Genetic Interaction Map Project]

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======= SH3PXD2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3PXD2B
  * **<color #00a2e8>Official Name</color>**: SH3 and PX domains 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285590|285590]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1X283|A1X283]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3PXD2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3PXD2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH3 1|
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of brood size|
|osteoblast fate commitment|
|podosome assembly|
|positive regulation of adipose tissue development|
|regulation of adipose tissue development|
|superoxide-generating NADPH oxidase activator activity|
|phosphatidylinositol-5-phosphate binding|
|phosphatidylinositol-3,5-bisphosphate binding|
|podosome|
|phosphatidylinositol-4-phosphate binding|
|positive regulation of multicellular organism growth|
|SH2 domain binding|
|adipose tissue development|
|superoxide metabolic process|
|phosphatidylinositol-3-phosphate binding|
|positive regulation of stress fiber assembly|
|positive regulation of fat cell differentiation|
|positive regulation of actin filament bundle assembly|
|extracellular matrix disassembly|
|regulation of multicellular organism growth|
|cranial skeletal system development|
|regulation of stress fiber assembly|
|phosphatidylinositol binding|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|cell projection|
|reactive oxygen species metabolic process|
|regulation of fat cell differentiation|
|osteoblast differentiation|
|positive regulation of developmental growth|
|positive regulation of supramolecular fiber organization|
|bone development|
|multi-multicellular organism process|
|positive regulation of cytoskeleton organization|
|connective tissue development|
|skeletal system morphogenesis|
|cell fate commitment|
|positive regulation of growth|
|regulation of actin filament organization|
|ossification|
|regulation of developmental growth|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|sensory system development|
|extracellular structure organization|
|regulation of actin filament-based process|
|cellular component disassembly|
|protein localization to membrane|
|skeletal system development|
|positive regulation of cellular component biogenesis|
|heart development|
|regulation of cytoskeleton organization|
|sensory organ development|
|cell junction|
|positive regulation of organelle organization|
|regulation of growth|
|organelle assembly|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|circulatory system development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3PXD2B Expression in NALM6 Cells: 2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>