SHOX2 [The Human Chemical-Genetic Interaction Map Project]

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======= SHOX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHOX2
  * **<color #00a2e8>Official Name</color>**: short stature homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6474|6474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60902|O60902]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHOX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHOX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OAR|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of branching morphogenesis of a nerve|
|positive regulation of skeletal muscle fiber development|
|embryonic skeletal joint morphogenesis|
|regulation of skeletal muscle fiber development|
|embryonic skeletal joint development|
|embryonic digestive tract morphogenesis|
|positive regulation of mesenchymal cell proliferation|
|positive regulation of skeletal muscle tissue development|
|cardiac atrium morphogenesis|
|positive regulation of smoothened signaling pathway|
|positive regulation of myotube differentiation|
|embryonic forelimb morphogenesis|
|regulation of mesenchymal cell proliferation|
|embryonic digestive tract development|
|cardiac atrium development|
|forelimb morphogenesis|
|chondrocyte development|
|cartilage development involved in endochondral bone morphogenesis|
|digestive tract morphogenesis|
|regulation of skeletal muscle tissue development|
|regulation of chondrocyte differentiation|
|regulation of morphogenesis of a branching structure|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|heart valve development|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|regulation of cartilage development|
|positive regulation of muscle tissue development|
|endochondral bone morphogenesis|
|regulation of smoothened signaling pathway|
|muscle tissue morphogenesis|
|chondrocyte differentiation|
|positive regulation of axonogenesis|
|positive regulation of muscle cell differentiation|
|muscle organ morphogenesis|
|embryonic skeletal system morphogenesis|
|regulation of striated muscle cell differentiation|
|bone morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|osteoblast differentiation|
|cardiac chamber morphogenesis|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|limb morphogenesis|
|appendage morphogenesis|
|regulation of muscle cell differentiation|
|positive regulation of cell morphogenesis involved in differentiation|
|cardiac chamber development|
|cartilage development|
|appendage development|
|limb development|
|regulation of axonogenesis|
|bone development|
|connective tissue development|
|skeletal system morphogenesis|
|heart morphogenesis|
|ossification|
|positive regulation of neuron projection development|
|embryonic organ morphogenesis|
|muscle organ development|
|regulation of cell morphogenesis involved in differentiation|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|sequence-specific DNA binding|
|embryonic organ development|
|positive regulation of neurogenesis|
|muscle structure development|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.02|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.99|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHOX2 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>