SIX1 [The Human Chemical-Genetic Interaction Map Project]

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======= SIX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIX1
  * **<color #00a2e8>Official Name</color>**: SIX homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6495|6495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15475|Q15475]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox KN|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to 3,3,5-triiodo-L-thyronine|
|response to 3,3,5-triiodo-L-thyronine|
|positive regulation of mesenchymal cell proliferation involved in ureter development|
|myotome development|
|olfactory placode formation|
|ureter smooth muscle cell differentiation|
|olfactory placode morphogenesis|
|olfactory placode development|
|positive regulation of secondary heart field cardioblast proliferation|
|regulation of mesenchymal cell proliferation involved in ureter development|
|ureter smooth muscle development|
|regulation of ureteric bud formation|
|regulation of branch elongation involved in ureteric bud branching|
|positive regulation of ureteric bud formation|
|positive regulation of epithelial tube formation|
|regulation of synaptic growth at neuromuscular junction|
|trigeminal ganglion development|
|fungiform papilla morphogenesis|
|fungiform papilla development|
|cranial ganglion development|
|mesonephric tubule formation|
|tongue morphogenesis|
|regulation of secondary heart field cardioblast proliferation|
|regulation of cardioblast proliferation|
|facial nerve morphogenesis|
|regulation of neuromuscular junction development|
|ectodermal placode formation|
|ectodermal placode morphogenesis|
|facial nerve development|
|ectodermal placode development|
|myoblast migration|
|regulation of skeletal muscle satellite cell proliferation|
|regulation of skeletal muscle cell proliferation|
|metanephric mesenchyme development|
|otic vesicle development|
|ureter development|
|organ induction|
|nose development|
|ganglion development|
|cellular response to thyroid hormone stimulus|
|smooth muscle tissue development|
|nephron tubule formation|
|regulation of cell proliferation involved in heart morphogenesis|
|preganglionic parasympathetic fiber development|
|kidney mesenchyme development|
|positive regulation of branching involved in ureteric bud morphogenesis|
|parasympathetic nervous system development|
|regulation of skeletal muscle cell differentiation|
|regulation of epithelial tube formation|
|tongue development|
|middle ear morphogenesis|
|transcription coactivator binding|
|positive regulation of mesonephros development|
|muscle cell migration|
|thyroid gland development|
|regulation of branching involved in ureteric bud morphogenesis|
|skeletal muscle fiber development|
|cochlea morphogenesis|
|positive regulation of mesenchymal cell proliferation|
|regulation of mesonephros development|
|response to thyroid hormone|
|pharyngeal system development|
|myotube cell development|
|developmental induction|
|aorta morphogenesis|
|cranial nerve morphogenesis|
|smooth muscle cell differentiation|
|neuron fate specification|
|regulation of mesenchymal cell proliferation|
|positive regulation of morphogenesis of an epithelium|
|regulation of animal organ formation|
|positive regulation of embryonic development|
|regulation of heart morphogenesis|
|positive regulation of kidney development|
|branching involved in ureteric bud morphogenesis|
|embryonic cranial skeleton morphogenesis|
|autonomic nervous system development|
|thymus development|
|regulation of skeletal muscle tissue development|
|cochlea development|
|aorta development|
|cranial nerve development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|myotube differentiation|
|muscle fiber development|
|artery morphogenesis|
|neuron fate commitment|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|cranial skeletal system development|
|nephron morphogenesis|
|renal tubule morphogenesis|
|cellular response to amino acid stimulus|
|outflow tract morphogenesis|
|transcription regulatory region sequence-specific DNA binding|
|nephron tubule development|
|nerve development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|somite development|
|metanephros development|
|kidney morphogenesis|
|artery development|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|cell fate specification|
|mesonephros development|
|embryonic skeletal system morphogenesis|
|nephron epithelium development|
|inner ear morphogenesis|
|regulation of synapse assembly|
|response to amino acid|
|ear morphogenesis|
|endocrine system development|
|skeletal muscle tissue development|
|embryonic epithelial tube formation|
|nephron development|
|embryonic skeletal system development|
|regulation of embryonic development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|morphogenesis of embryonic epithelium|
|negative regulation of neuron apoptotic process|
|sensory perception of sound|
|tube formation|
|muscle cell development|
|morphogenesis of a branching epithelium|
|protein localization to nucleus|
|sensory perception of mechanical stimulus|
|morphogenesis of a branching structure|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|respiratory system development|
|striated muscle cell differentiation|
|transcription factor complex|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to acid chemical|
|regulation of synapse organization|
|transcription regulatory region DNA binding|
|mesenchyme development|
|ear development|
|regulation of synapse structure or activity|
|skeletal system morphogenesis|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|kidney development|
|striated muscle tissue development|
|renal system development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|regulation of neuron death|
|urogenital system development|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|response to acid chemical|
|chromatin binding|
|blood vessel morphogenesis|
|gland development|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|cellular response to organic cyclic compound|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|protein localization to organelle|
|regulation of neurogenesis|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|sensory perception|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIX1 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>