SLC18A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC18A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC18A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 18 member A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6571|6571]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05940|Q05940]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC18A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC18A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193001|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sugar tr|
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of neurotransmitter|
|serotonin uptake|
|serotonin:sodium symporter activity|
|aminergic neurotransmitter loading into synaptic vesicle|
|clathrin-sculpted monoamine transport vesicle membrane|
|monoamine transmembrane transporter activity|
|serotonin transport|
|amine transport|
|neurotransmitter loading into synaptic vesicle|
|dopamine transport|
|dopaminergic synapse|
|catecholamine transport|
|neurotransmitter reuptake|
|monoamine transport|
|negative regulation of reactive oxygen species biosynthetic process|
|neurotransmitter uptake|
|response to amphetamine|
|response to amine|
|terminal bouton|
|response to bronchodilator|
|ammonium transport|
|negative regulation of reactive oxygen species metabolic process|
|synaptic vesicle membrane|
|regulation of reactive oxygen species biosynthetic process|
|post-embryonic development|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|organic hydroxy compound transport|
|drug transport|
|maintenance of location|
|signal release|
|regulation of reactive oxygen species metabolic process|
|neurotransmitter transport|
|locomotory behavior|
|response to xenobiotic stimulus|
|regulation of neurotransmitter levels|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|behavior|
|import into cell|
|cation transport|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|negative regulation of biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9179
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC18A2 Expression in NALM6 Cells: 3.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>