SLC22A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC22A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC22A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 22 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6581|6581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75751|O75751]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC22A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC22A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604842|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine uptake|
|quaternary ammonium group transmembrane transporter activity|
|dopamine:sodium symporter activity|
|toxin transmembrane transporter activity|
|organic cation transmembrane transporter activity|
|dopamine uptake|
|histamine transport|
|catecholamine uptake|
|dopamine transport|
|quaternary ammonium group transport|
|catecholamine transport|
|azole transport|
|monoamine transport|
|regulation of appetite|
|neurotransmitter uptake|
|organic cation transport|
|toxin transport|
|ammonium transport|
|drug transmembrane transport|
|organic hydroxy compound transport|
|drug transport|
|neurotransmitter transport|
|regulation of neurotransmitter levels|
|response to nutrient levels|
|response to extracellular stimulus|
|import into cell|
|cation transport|
|response to drug|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.18|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.12|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.92|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.77|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.76|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC22A3 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>