SLC25A12 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A12
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8604|8604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75746|O75746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO:0000269|PubMed:11566871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glucose catabolic process to lactate via pyruvate|
|negative regulation of NAD metabolic process|
|regulation of NAD metabolic process|
|negative regulation of fermentation|
|regulation of glucose catabolic process to lactate via pyruvate|
|malate-aspartate shuttle|
|regulation of fermentation|
|L-aspartate transmembrane transporter activity|
|glutamate biosynthetic process|
|L-aspartate transmembrane transport|
|aspartate transmembrane transport|
|L-glutamate transmembrane transporter activity|
|positive regulation of ATP biosynthetic process|
|dicarboxylic acid biosynthetic process|
|positive regulation of myelination|
|regulation of ATP biosynthetic process|
|L-glutamate transmembrane transport|
|glutamine family amino acid biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of nucleotide biosynthetic process|
|C4-dicarboxylate transport|
|negative regulation of ATP metabolic process|
|glutamate metabolic process|
|positive regulation of glucose metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|regulation of myelination|
|gluconeogenesis|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|hexose biosynthetic process|
|negative regulation of carbohydrate metabolic process|
|monosaccharide biosynthetic process|
|positive regulation of cellular carbohydrate metabolic process|
|L-amino acid transport|
|positive regulation of nervous system process|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|positive regulation of carbohydrate metabolic process|
|cellular amino acid biosynthetic process|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|mitochondrial transmembrane transport|
|dicarboxylic acid metabolic process|
|respiratory electron transport chain|
|regulation of glucose metabolic process|
|glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|amino acid transport|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|drug transport|
|response to calcium ion|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular respiration|
|neurotransmitter transport|
|electron transport chain|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|alpha-amino acid metabolic process|
|mitochondrial transport|
|energy derivation by oxidation of organic compounds|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|negative regulation of catabolic process|
|response to metal ion|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|organic anion transport|
|carbohydrate metabolic process|
|response to inorganic substance|
|positive regulation of nervous system development|
|anion transport|
|regulation of system process|
|small molecule biosynthetic process|
|calcium ion binding|
|carboxylic acid metabolic process|
|regulation of nervous system development|
|ion transmembrane transport|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|identical protein binding|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|mitochondrion|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|organonitrogen compound biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.09|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A12 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>