SLC25A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6576|6576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53007|P53007]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190315|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|citrate secondary active transmembrane transporter activity|
|mitochondrial tricarboxylic acid transmembrane transport|
|tricarboxylic acid transmembrane transporter activity|
|mitochondrial citrate transmembrane transport|
|tricarboxylic acid transmembrane transport|
|citrate transport|
|tricarboxylic acid transport|
|citrate transmembrane transporter activity|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|gluconeogenesis|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|fatty acid derivative biosynthetic process|
|mitochondrial transmembrane transport|
|thioester metabolic process|
|acyl-CoA metabolic process|
|glucose metabolic process|
|carbohydrate biosynthetic process|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|hexose metabolic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monosaccharide metabolic process|
|cofactor biosynthetic process|
|mitochondrial transport|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|carbohydrate metabolic process|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|anion transport|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.47|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.59|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.49|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.33|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.18|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.05|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.04|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.89|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.7|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.73|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.73|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.73|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.73|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.74|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.75|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.79|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.83|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.87|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.94|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.97|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.01|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.02|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.07|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.15|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.18|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.23|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.33|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.38|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.39|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.44|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.49|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.52|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.61|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.67|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.75|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brd1|BRD1]]|0.442|
|[[:human genes:s:scap|SCAP]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A1 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>