SLC25A28 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A28
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81894|81894]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A46|Q96A46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron import into the mitochondrion|
|iron ion transmembrane transporter activity|
|iron ion transmembrane transport|
|iron ion transport|
|iron ion homeostasis|
|mitochondrial transmembrane transport|
|transition metal ion transport|
|transition metal ion homeostasis|
|mitochondrial transport|
|mitochondrial inner membrane|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.66|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.43|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.18|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.95|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.73|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.72|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.83|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.86|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.9|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|5/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A28 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>