SLC25A32 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A32
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81034|81034]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2D1|Q9H2D1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transports folate across the inner membranes of mitochondria.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|folate import into mitochondrion|
|FAD transmembrane transporter activity|
|FAD transmembrane transport|
|folic acid transmembrane transporter activity|
|folate transmembrane transport|
|nucleotide transmembrane transport|
|folic acid transport|
|vitamin transmembrane transport|
|glycine metabolic process|
|folic acid metabolic process|
|nucleotide transport|
|modified amino acid transport|
|folic acid-containing compound metabolic process|
|pteridine-containing compound metabolic process|
|vitamin transport|
|serine family amino acid metabolic process|
|cofactor transport|
|drug transmembrane transport|
|dicarboxylic acid transport|
|water-soluble vitamin metabolic process|
|neurotransmitter metabolic process|
|mitochondrial transmembrane transport|
|dicarboxylic acid metabolic process|
|organophosphate ester transport|
|vitamin metabolic process|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|mitochondrial transport|
|nucleobase-containing compound transport|
|coenzyme metabolic process|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cellular amino acid metabolic process|
|regulation of neurotransmitter levels|
|mitochondrial inner membrane|
|cofactor metabolic process|
|organic anion transport|
|drug metabolic process|
|anion transport|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|mitochondrion|
|transmembrane transport|
|ion transport|
|amide transport|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-3.52|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.94|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.72|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.75|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.84|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.84|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.85|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.86|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.88|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.9|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.91|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.94|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.95|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.95|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.96|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.97|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.05|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.12|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.13|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.13|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.14|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.15|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.16|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.24|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.26|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.26|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.3|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.41|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.49|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.5|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.59|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.12|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|3.14|
|[[:results:exp274|Citral 50μM R06 exp274]]|3.29|
|[[:results:exp116|AICAR 240μM R03 exp116]]|5.3|
|[[:results:exp211|AICAR 240μM R05 exp211]]|6.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mthfd2|MTHFD2]]|0.658|
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.654|
|[[:human genes:s:shmt2|SHMT2]]|0.641|
|[[:human genes:m:mtr|MTR]]|0.538|
|[[:human genes:m:mtrr|MTRR]]|0.531|
|[[:human genes:m:mmachc|MMACHC]]|0.478|
|[[:human genes:s:sfxn1|SFXN1]]|0.429|
|[[:human genes:a:ak2|AK2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2098
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A32 Expression in NALM6 Cells: 5.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>