SLC26A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC26A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC26A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 26 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1811|1811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40879|P40879]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC26A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC26A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAS|
|Sulfate transp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular pH elevation|
|pH elevation|
|membrane hyperpolarization|
|oxalate transmembrane transporter activity|
|oxalate transport|
|secondary active sulfate transmembrane transporter activity|
|bicarbonate transmembrane transporter activity|
|sulfate transmembrane transporter activity|
|sulfate transmembrane transport|
|chloride transmembrane transporter activity|
|sulfate transport|
|anion:anion antiporter activity|
|sperm midpiece|
|sperm capacitation|
|transporter activity|
|bicarbonate transport|
|excretion|
|sulfur compound transport|
|brush border membrane|
|cellular response to cAMP|
|dicarboxylic acid transport|
|transcription coregulator activity|
|regulation of intracellular pH|
|chloride transmembrane transport|
|regulation of cellular pH|
|regulation of pH|
|response to cAMP|
|chloride transport|
|cellular monovalent inorganic cation homeostasis|
|inorganic anion transmembrane transport|
|response to organophosphorus|
|monovalent inorganic cation homeostasis|
|spermatid development|
|response to purine-containing compound|
|spermatid differentiation|
|cell maturation|
|inorganic anion transport|
|developmental maturation|
|germ cell development|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|apical plasma membrane|
|cellular process involved in reproduction in multicellular organism|
|regulation of membrane potential|
|organic anion transport|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|anion transport|
|cellular response to organonitrogen compound|
|cellular cation homeostasis|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular homeostasis|
|response to organic cyclic compound|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC26A3 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>