SLC26A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC26A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC26A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 26 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375611|375611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58743|P58743]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC26A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC26A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfate transp|
|STAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to salicylic acid|
|fructose transmembrane transport|
|oxalate transmembrane transporter activity|
|oxalate transport|
|positive regulation of cell size|
|secondary active sulfate transmembrane transporter activity|
|bicarbonate transmembrane transporter activity|
|response to potassium ion|
|sulfate transmembrane transporter activity|
|sulfate transmembrane transport|
|chloride transmembrane transporter activity|
|sulfate transport|
|response to salt|
|anion:anion antiporter activity|
|response to auditory stimulus|
|response to thyroid hormone|
|spectrin binding|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|bicarbonate transport|
|sulfur compound transport|
|response to ischemia|
|cochlea development|
|lateral plasma membrane|
|carbohydrate transport|
|dicarboxylic acid transport|
|chloride transmembrane transport|
|negative regulation of ion transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|negative regulation of transmembrane transport|
|sensory perception of sound|
|negative regulation of ion transport|
|protein tetramerization|
|regulation of cell shape|
|inorganic anion transport|
|sensory perception of mechanical stimulus|
|regulation of cell size|
|inner ear development|
|basolateral plasma membrane|
|response to mechanical stimulus|
|ear development|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|response to antibiotic|
|transcription factor binding|
|response to acid chemical|
|response to metal ion|
|regulation of cellular component size|
|regulation of membrane potential|
|organic anion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of anatomical structure size|
|protein complex oligomerization|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|sensory organ development|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|anion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|regulation of anatomical structure morphogenesis|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC26A5 Expression in NALM6 Cells: -2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>