SLC26A6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC26A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC26A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 26 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65010|65010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXS9|Q9BXS9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC26A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC26A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610068|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride- oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfate transp|
|STAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formate transmembrane transporter activity|
|formate efflux transmembrane transporter activity|
|formate transport|
|mannitol transport|
|regulation of oligopeptide transport|
|positive regulation of dipeptide transmembrane transport|
|oxalic acid secretion|
|positive regulation of dipeptide transport|
|positive regulation of oligopeptide transport|
|regulation of dipeptide transport|
|regulation of dipeptide transmembrane transport|
|cellular response to fructose stimulus|
|efflux transmembrane transporter activity|
|transepithelial chloride transport|
|intracellular pH elevation|
|pH elevation|
|response to fructose|
|epithelial fluid transport|
|oxalate transmembrane transporter activity|
|secondary active sulfate transmembrane transporter activity|
|oxalate transport|
|polyol transport|
|bicarbonate transmembrane transporter activity|
|sulfate transmembrane transporter activity|
|chloride transmembrane transporter activity|
|sulfate transmembrane transport|
|transepithelial transport|
|sulfate transport|
|anion:anion antiporter activity|
|sperm midpiece|
|sperm capacitation|
|fluid transport|
|vesicle membrane|
|intestinal absorption|
|bicarbonate transport|
|sulfur compound transport|
|chloride channel complex|
|brush border membrane|
|cellular response to cAMP|
|chloride channel activity|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|digestive system process|
|carbohydrate transport|
|dicarboxylic acid transport|
|acid secretion|
|cellular response to carbohydrate stimulus|
|regulation of intracellular pH|
|PDZ domain binding|
|chloride transmembrane transport|
|regulation of cellular pH|
|regulation of pH|
|response to cAMP|
|chloride transport|
|cellular monovalent inorganic cation homeostasis|
|inorganic anion transmembrane transport|
|digestion|
|response to organophosphorus|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|monovalent inorganic cation homeostasis|
|vesicle|
|response to hexose|
|cytoplasmic vesicle membrane|
|drug transport|
|response to monosaccharide|
|spermatid development|
|response to purine-containing compound|
|spermatid differentiation|
|cell maturation|
|inorganic anion transport|
|cellular response to interferon-gamma|
|response to carbohydrate|
|response to interferon-gamma|
|basolateral plasma membrane|
|positive regulation of transmembrane transport|
|developmental maturation|
|germ cell development|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|apical plasma membrane|
|cellular process involved in reproduction in multicellular organism|
|organic anion transport|
|cellular response to organic cyclic compound|
|spermatogenesis|
|regulation of transmembrane transport|
|male gamete generation|
|anion transport|
|cellular response to organonitrogen compound|
|cellular cation homeostasis|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|innate immune response|
|ion homeostasis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular homeostasis|
|response to organic cyclic compound|
|ion transmembrane transport|
|defense response to other organism|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|regulation of transport|
|immune response|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9780
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC26A6 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>