SLC2A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC2A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC2A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 2 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6513|6513]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11166|P11166]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC2A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC2A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D-glucose transmembrane transporter activity|
|lactose biosynthetic process|
|lactose metabolic process|
|response to Thyroglobulin triiodothyronine|
|disaccharide biosynthetic process|
|dehydroascorbic acid transport|
|dehydroascorbic acid transmembrane transporter activity|
|xenobiotic transmembrane transporter activity|
|female pronucleus|
|L-ascorbic acid metabolic process|
|cellular hyperosmotic response|
|disaccharide metabolic process|
|glucose transmembrane transporter activity|
|oligosaccharide biosynthetic process|
|xenobiotic transport|
|hyperosmotic response|
|glucose transmembrane transport|
|cellular response to osmotic stress|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|vitamin transport|
|cellular response to glucose starvation|
|intercalated disc|
|oligosaccharide metabolic process|
|cortical actin cytoskeleton|
|protein self-association|
|cellular carbohydrate biosynthetic process|
|regulation of glucose transmembrane transport|
|caveola|
|carbohydrate transport|
|response to osmotic stress|
|cellular response to mechanical stimulus|
|water-soluble vitamin metabolic process|
|kinase binding|
|sarcolemma|
|melanosome|
|cerebral cortex development|
|vitamin metabolic process|
|carbohydrate biosynthetic process|
|Z disc|
|blood microparticle|
|cellular response to starvation|
|midbody|
|cellular carbohydrate metabolic process|
|pallium development|
|regulation of insulin secretion|
|female pregnancy|
|response to starvation|
|basolateral plasma membrane|
|monosaccharide metabolic process|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|response to mechanical stimulus|
|response to insulin|
|cellular response to nutrient levels|
|coenzyme metabolic process|
|telencephalon development|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|cellular response to external stimulus|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|forebrain development|
|response to peptide hormone|
|cofactor metabolic process|
|organic anion transport|
|regulation of protein secretion|
|response to peptide|
|carbohydrate metabolic process|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of transmembrane transport|
|anion transport|
|Golgi membrane|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|response to hormone|
|carboxylic acid metabolic process|
|central nervous system development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|identical protein binding|
|response to nitrogen compound|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular response to stress|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.4|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.7|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.73|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.74|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.82|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.85|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.86|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.86|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.88|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.89|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.94|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.96|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.13|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.17|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.18|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.19|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.25|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.28|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.28|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.3|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.61|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.63|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.65|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfkp|PFKP]]|0.599|
|[[:human genes:h:hk2|HK2]]|0.564|
|[[:human genes:g:gpi|GPI]]|0.538|
|[[:human genes:p:pgp|PGP]]|0.491|
|[[:human genes:h:hk1|HK1]]|0.479|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 86/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|4/26|
|breast|3/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|18/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC2A1 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>