SLC30A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC30A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC30A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 30 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7779|7779]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6M5|Q9Y6M5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC30A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC30A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in zinc transport out of the cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation efflux|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detoxification of cadmium ion|
|regulation of zinc ion transmembrane import|
|stress response to cadmium ion|
|regulation of zinc ion transmembrane transport|
|negative regulation of zinc ion transport|
|negative regulation of zinc ion transmembrane import|
|negative regulation of zinc ion transmembrane transport|
|regulation of zinc ion transport|
|cadmium ion transport|
|cadmium ion transmembrane transport|
|negative regulation of calcium ion import|
|calcium channel inhibitor activity|
|negative regulation of neurotransmitter secretion|
|detoxification of inorganic compound|
|stress response to metal ion|
|zinc ion transmembrane transporter activity|
|zinc ion transmembrane transport|
|negative regulation of neurotransmitter transport|
|zinc ion transport|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|regulation of calcium ion import|
|T-tubule|
|calcium ion import|
|integral component of postsynaptic density membrane|
|negative regulation of calcium ion transport|
|negative regulation of synaptic transmission|
|response to cadmium ion|
|Schaffer collateral - CA1 synapse|
|negative regulation of cation transmembrane transport|
|negative regulation of ion transmembrane transport|
|regulation of neurotransmitter secretion|
|cellular transition metal ion homeostasis|
|negative regulation of transmembrane transport|
|transition metal ion transport|
|detoxification|
|transition metal ion homeostasis|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|nuclear membrane|
|regulation of calcium ion transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|regulation of neurotransmitter levels|
|response to metal ion|
|in utero embryonic development|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|response to inorganic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|chordate embryonic development|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|embryo development ending in birth or egg hatching|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|embryo development|
|Golgi apparatus|
|endoplasmic reticulum|
|chemical homeostasis|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|homeostatic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-4.1|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-3.95|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-3.31|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.89|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.58|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.24|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.99|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.71|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.94|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11099
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC30A1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>