SLC30A9 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC30A9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC30A9
  * **<color #00a2e8>Official Name</color>**: solute carrier family 30 member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10463|10463]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PML9|Q6PML9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC30A9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC30A9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604604|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity). {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation efflux|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cation transmembrane transporter activity|
|nuclear receptor binding|
|zinc ion transport|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|nuclear receptor transcription coactivator activity|
|cellular transition metal ion homeostasis|
|nucleotide-excision repair|
|transition metal ion transport|
|transition metal ion homeostasis|
|cytoplasmic vesicle|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cytoskeleton|
|chromatin binding|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|DNA repair|
|cellular metal ion homeostasis|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|DNA-binding transcription factor activity|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|endoplasmic reticulum|
|chemical homeostasis|
|positive regulation of transcription by RNA polymerase II|
|transmembrane transport|
|ion transport|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.87|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.71|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.81|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.89|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.96|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.18|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.52|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.48|
|[[:human genes:p:pde12|PDE12]]|0.477|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.464|
|[[:human genes:d:ddx28|DDX28]]|0.425|
|[[:human genes:t:timm8a|TIMM8A]]|0.416|
|[[:human genes:p:prepl|PREPL]]|0.413|
|[[:human genes:c:cox6a1|COX6A1]]|0.412|
|[[:human genes:m:micu2|MICU2]]|0.411|
|[[:human genes:m:mtif2|MTIF2]]|0.41|
|[[:human genes:e:eral1|ERAL1]]|0.408|
|[[:human genes:c:clpx|CLPX]]|0.405|
|[[:human genes:f:fastkd2|FASTKD2]]|0.4|
|[[:human genes:c:clpp|CLPP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC30A9 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>