SLC32A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC32A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC32A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 32 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140679|140679]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H598|Q9H598]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC32A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC32A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the uptake of GABA and glycine into the synaptic vesicles. {ECO:0000250|UniProtKB:O35458}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-aminobutyric acid:proton symporter activity|
|cone cell pedicle|
|dendrite terminus|
|cell tip|
|glycine transmembrane transporter activity|
|gamma-aminobutyric acid transport|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|neurotransmitter loading into synaptic vesicle|
|glycine transport|
|inhibitory synapse|
|neuron projection terminus|
|integral component of synaptic vesicle membrane|
|presynaptic active zone|
|neutral amino acid transport|
|amino acid transmembrane transporter activity|
|L-amino acid transport|
|GABA-ergic synapse|
|synaptic vesicle membrane|
|amino acid transmembrane transport|
|hippocampus development|
|signal release from synapse|
|neurotransmitter secretion|
|limbic system development|
|amino acid transport|
|synaptic vesicle cycle|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|vesicle-mediated transport in synapse|
|monocarboxylic acid transport|
|drug transport|
|signal release|
|pallium development|
|neurotransmitter transport|
|telencephalon development|
|anion transmembrane transport|
|aging|
|carboxylic acid transport|
|organic acid transport|
|neuron projection|
|regulation of neurotransmitter levels|
|forebrain development|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|anion transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|central nervous system development|
|secretion by cell|
|response to drug|
|export from cell|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.98|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.94|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.8|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.89|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC32A1 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>