SLC37A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC37A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC37A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 37 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2542|2542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43826|O43826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC37A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC37A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6- phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:10026167, ECO:0000269|PubMed:21949678}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucose-6-phosphate transmembrane transporter activity|
|glucose 6-phosphate:inorganic phosphate antiporter activity|
|hexose phosphate transport|
|glucose-6-phosphate transport|
|phosphate ion transmembrane transport|
|phosphate ion transport|
|gluconeogenesis|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|carbohydrate derivative transport|
|carbohydrate transport|
|integral component of endoplasmic reticulum membrane|
|inorganic anion transmembrane transport|
|glucose metabolic process|
|organophosphate ester transport|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|inorganic anion transport|
|monosaccharide metabolic process|
|anion transmembrane transport|
|organic anion transport|
|carbohydrate metabolic process|
|anion transport|
|small molecule biosynthetic process|
|inorganic ion transmembrane transport|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|endoplasmic reticulum|
|transmembrane transport|
|ion transport|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.77|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.71|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.95|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC37A4 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>