SLC4A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC4A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC4A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 4 member 1 (Diego blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6521|6521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02730|P02730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC4A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC4A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 3 cyto|
|HCO3 cotransp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anion transmembrane transporter activity|
|negative regulation of urine volume|
|hemoglobin binding|
|pH elevation|
|inorganic anion exchanger activity|
|bicarbonate transmembrane transporter activity|
|protein membrane anchor|
|chloride transmembrane transporter activity|
|plasma membrane phospholipid scrambling|
|cortical cytoskeleton|
|ankyrin binding|
|anion:anion antiporter activity|
|regulation of urine volume|
|erythrocyte development|
|bicarbonate transport|
|glycolytic process|
|ATP generation from ADP|
|phospholipid translocation|
|lipid translocation|
|ADP metabolic process|
|regulation of membrane lipid distribution|
|cytoplasmic side of plasma membrane|
|myeloid cell development|
|nucleoside diphosphate phosphorylation|
|purine nucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|erythrocyte differentiation|
|nucleoside diphosphate metabolic process|
|regulation of intracellular pH|
|chloride transmembrane transport|
|erythrocyte homeostasis|
|regulation of cellular pH|
|phospholipid transport|
|plasma membrane organization|
|regulation of pH|
|chloride transport|
|myeloid cell homeostasis|
|cellular monovalent inorganic cation homeostasis|
|inorganic anion transmembrane transport|
|renal system process|
|carbohydrate catabolic process|
|organophosphate ester transport|
|Z disc|
|monovalent inorganic cation homeostasis|
|blood microparticle|
|inorganic anion transport|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|homeostasis of number of cells|
|ATP metabolic process|
|myeloid cell differentiation|
|protein localization to cell periphery|
|anion transmembrane transport|
|blood coagulation|
|coagulation|
|lipid transport|
|hemostasis|
|purine ribonucleotide metabolic process|
|lipid localization|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|endomembrane system organization|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|carbohydrate metabolic process|
|wound healing|
|protein localization to membrane|
|regulation of body fluid levels|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|hemopoiesis|
|response to wounding|
|anion transport|
|hematopoietic or lymphoid organ development|
|cellular cation homeostasis|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|membrane organization|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|transmembrane transport|
|phosphorylation|
|ion transport|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.7|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.77|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.78|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.88|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.99|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.06|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.08|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.12|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.6|
|[[:human genes:c:chd4|CHD4]]|0.572|
|[[:human genes:t:tceb3c|TCEB3C]]|0.556|
|[[:human genes:c:c14orf93|C14orf93]]|0.554|
|[[:human genes:r:rad51|RAD51]]|0.543|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.543|
|[[:human genes:t:tfip11|TFIP11]]|0.541|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.536|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.536|
|[[:human genes:m:mt1e|MT1E]]|0.534|
|[[:human genes:p:prim1|PRIM1]]|0.531|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.527|
|[[:human genes:c:cbwd3|CBWD3]]|0.523|
|[[:human genes:p:psmb4|PSMB4]]|0.523|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.522|
|[[:human genes:t:ticrr|TICRR]]|0.521|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.52|
|[[:human genes:s:syt9|SYT9]]|0.519|
|[[:human genes:c:copg1|COPG1]]|0.518|
|[[:human genes:p:psmb2|PSMB2]]|0.517|
|[[:human genes:s:supt5h|SUPT5H]]|0.516|
|[[:human genes:p:psmd3|PSMD3]]|0.515|
|[[:human genes:n:npipb5|NPIPB5]]|0.512|
|[[:human genes:p:psmc1|PSMC1]]|0.51|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.508|
|[[:human genes:u:utp3|UTP3]]|0.508|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.507|
|[[:human genes:o:orc1|ORC1]]|0.507|
|[[:human genes:c:cdc45|CDC45]]|0.506|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.506|
|[[:human genes:c:cdh24|CDH24]]|0.505|
|[[:human genes:o:orc6|ORC6]]|0.503|
|[[:human genes:p:pole|POLE]]|0.503|
|[[:human genes:c:col2a1|COL2A1]]|0.501|
|[[:human genes:t:tyms|TYMS]]|0.501|
|[[:human genes:d:ddtl|DDTL]]|0.5|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.497|
|[[:human genes:n:nup153|NUP153]]|0.497|
|[[:human genes:r:rpl35|RPL35]]|0.497|
|[[:human genes:n:napa|NAPA]]|0.493|
|[[:human genes:c:copa|COPA]]|0.493|
|[[:human genes:r:rrp7a|RRP7A]]|0.493|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.492|
|[[:human genes:c:cbwd5|CBWD5]]|0.491|
|[[:human genes:a:acsf2|ACSF2]]|0.491|
|[[:human genes:c:cbwd6|CBWD6]]|0.491|
|[[:human genes:p:polr2f|POLR2F]]|0.488|
|[[:human genes:i:ik|IK]]|0.488|
|[[:human genes:a:aqr|AQR]]|0.487|
|[[:human genes:k:krt78|KRT78]]|0.486|
|[[:human genes:p:psma6|PSMA6]]|0.484|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.483|
|[[:human genes:c:ccna2|CCNA2]]|0.483|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.483|
|[[:human genes:u:upf1|UPF1]]|0.483|
|[[:human genes:a:aatf|AATF]]|0.483|
|[[:human genes:c:cope|COPE]]|0.481|
|[[:human genes:d:dock6|DOCK6]]|0.481|
|[[:human genes:p:psmc2|PSMC2]]|0.479|
|[[:human genes:r:rps2|RPS2]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.478|
|[[:human genes:a:abhd8|ABHD8]]|0.477|
|[[:human genes:c:chaf1a|CHAF1A]]|0.477|
|[[:human genes:r:rrp15|RRP15]]|0.477|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:k:kctd17|KCTD17]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.474|
|[[:human genes:p:pola2|POLA2]]|0.473|
|[[:human genes:d:dtl|DTL]]|0.473|
|[[:human genes:g:golga6a|GOLGA6A]]|0.473|
|[[:human genes:c:cactin|CACTIN]]|0.472|
|[[:human genes:p:polr2j|POLR2J]]|0.472|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.471|
|[[:human genes:t:twistnb|TWISTNB]]|0.47|
|[[:human genes:h:hap1|HAP1]]|0.47|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.469|
|[[:human genes:p:pwp2|PWP2]]|0.469|
|[[:human genes:c:cdca3|CDCA3]]|0.469|
|[[:human genes:o:osbp|OSBP]]|0.469|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.468|
|[[:human genes:h:hinfp|HINFP]]|0.468|
|[[:human genes:i:ints5|INTS5]]|0.468|
|[[:human genes:r:riok2|RIOK2]]|0.467|
|[[:human genes:c:copb1|COPB1]]|0.467|
|[[:human genes:h:hivep3|HIVEP3]]|0.466|
|[[:human genes:a:ankle1|ANKLE1]]|0.465|
|[[:human genes:d:disp2|DISP2]]|0.465|
|[[:human genes:f:fam160a1|FAM160A1]]|0.465|
|[[:human genes:a:akirin2|AKIRIN2]]|0.463|
|[[:human genes:s:slc6a17|SLC6A17]]|0.462|
|[[:human genes:n:nupl1|NUPL1]]|0.461|
|[[:human genes:t:tsg101|TSG101]]|0.461|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.461|
|[[:human genes:g:golga8o|GOLGA8O]]|0.459|
|[[:human genes:k:kif3c|KIF3C]]|0.458|
|[[:human genes:s:ssh2|SSH2]]|0.457|
|[[:human genes:a:aamp|AAMP]]|0.457|
|[[:human genes:n:narfl|NARFL]]|0.456|
|[[:human genes:p:polr2d|POLR2D]]|0.456|
|[[:human genes:r:rbbp5|RBBP5]]|0.456|
|[[:human genes:g:gar1|GAR1]]|0.455|
|[[:human genes:t:tspy8|TSPY8]]|0.455|
|[[:human genes:r:rrn3|RRN3]]|0.454|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.453|
|[[:human genes:s:stil|STIL]]|0.453|
|[[:human genes:n:nup160|NUP160]]|0.453|
|[[:human genes:e:exosc9|EXOSC9]]|0.453|
|[[:human genes:i:igfn1|IGFN1]]|0.452|
|[[:human genes:r:rps20|RPS20]]|0.452|
|[[:human genes:i:ints6|INTS6]]|0.45|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.45|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.449|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.449|
|[[:human genes:r:ranbp2|RANBP2]]|0.449|
|[[:human genes:p:polr1a|POLR1A]]|0.448|
|[[:human genes:s:snrpa1|SNRPA1]]|0.448|
|[[:human genes:s:supt6h|SUPT6H]]|0.448|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.447|
|[[:human genes:n:nup43|NUP43]]|0.446|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.446|
|[[:human genes:u:uqcrh|UQCRH]]|0.446|
|[[:human genes:s:smtn|SMTN]]|0.446|
|[[:human genes:e:exd1|EXD1]]|0.446|
|[[:human genes:s:sf3a2|SF3A2]]|0.445|
|[[:human genes:z:znf830|ZNF830]]|0.443|
|[[:human genes:p:pan3|PAN3]]|0.442|
|[[:human genes:l:lrr1|LRR1]]|0.441|
|[[:human genes:p:paf1|PAF1]]|0.44|
|[[:human genes:m:mms22l|MMS22L]]|0.439|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.439|
|[[:human genes:r:rad21|RAD21]]|0.439|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.439|
|[[:human genes:p:psmd6|PSMD6]]|0.438|
|[[:human genes:d:ddx47|DDX47]]|0.438|
|[[:human genes:m:myo18a|MYO18A]]|0.438|
|[[:human genes:a:ankle2|ANKLE2]]|0.438|
|[[:human genes:o:or10g3|OR10G3]]|0.437|
|[[:human genes:a:arcn1|ARCN1]]|0.436|
|[[:human genes:t:tpx2|TPX2]]|0.435|
|[[:human genes:p:psmb3|PSMB3]]|0.435|
|[[:human genes:a:akt1s1|AKT1S1]]|0.434|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.433|
|[[:human genes:m:myo1h|MYO1H]]|0.433|
|[[:human genes:e:exosc3|EXOSC3]]|0.433|
|[[:human genes:e:egr2|EGR2]]|0.432|
|[[:human genes:s:slc38a7|SLC38A7]]|0.432|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.432|
|[[:human genes:p:plk1|PLK1]]|0.432|
|[[:human genes:s:snrnp200|SNRNP200]]|0.431|
|[[:human genes:n:nup85|NUP85]]|0.431|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.43|
|[[:human genes:n:nsf|NSF]]|0.43|
|[[:human genes:d:ddt|DDT]]|0.43|
|[[:human genes:s:sec13|SEC13]]|0.429|
|[[:human genes:c:ccdc116|CCDC116]]|0.429|
|[[:human genes:c:ctr9|CTR9]]|0.428|
|[[:human genes:d:dhx38|DHX38]]|0.428|
|[[:human genes:x:xylt2|XYLT2]]|0.427|
|[[:human genes:s:specc1l|SPECC1L]]|0.427|
|[[:human genes:p:plk4|PLK4]]|0.427|
|[[:human genes:c:cep192|CEP192]]|0.427|
|[[:human genes:l:loc643669|LOC643669]]|0.427|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.427|
|[[:human genes:c:cln6|CLN6]]|0.426|
|[[:human genes:m:mdm2|MDM2]]|0.426|
|[[:human genes:z:znf541|ZNF541]]|0.426|
|[[:human genes:g:gid4|GID4]]|0.425|
|[[:human genes:s:snrnp70|SNRNP70]]|0.424|
|[[:human genes:z:znf655|ZNF655]]|0.424|
|[[:human genes:s:snip1|SNIP1]]|0.424|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.424|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.424|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.423|
|[[:human genes:v:vps54|VPS54]]|0.423|
|[[:human genes:c:cdc6|CDC6]]|0.423|
|[[:human genes:c:copz1|COPZ1]]|0.422|
|[[:human genes:a:add2|ADD2]]|0.422|
|[[:human genes:f:fam25b|FAM25B]]|0.422|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.422|
|[[:human genes:p:pigs|PIGS]]|0.422|
|[[:human genes:m:mki67ip|MKI67IP]]|0.421|
|[[:human genes:r:rps5|RPS5]]|0.421|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.42|
|[[:human genes:s:sel1l|SEL1L]]|0.419|
|[[:human genes:t:timeless|TIMELESS]]|0.419|
|[[:human genes:m:med14|MED14]]|0.419|
|[[:human genes:p:psmd2|PSMD2]]|0.419|
|[[:human genes:o:ogfr|OGFR]]|0.419|
|[[:human genes:m:med17|MED17]]|0.418|
|[[:human genes:r:rps12|RPS12]]|0.417|
|[[:human genes:e:exosc5|EXOSC5]]|0.417|
|[[:human genes:v:vps28|VPS28]]|0.417|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.417|
|[[:human genes:r:rpsa|RPSA]]|0.416|
|[[:human genes:s:slc5a5|SLC5A5]]|0.416|
|[[:human genes:p:psmd1|PSMD1]]|0.416|
|[[:human genes:r:rps7|RPS7]]|0.415|
|[[:human genes:m:mbtd1|MBTD1]]|0.414|
|[[:human genes:w:wdr87|WDR87]]|0.412|
|[[:human genes:n:nop16|NOP16]]|0.412|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.412|
|[[:human genes:c:cdc73|CDC73]]|0.411|
|[[:human genes:r:rpl34|RPL34]]|0.411|
|[[:human genes:p:phf2|PHF2]]|0.409|
|[[:human genes:c:clasp1|CLASP1]]|0.409|
|[[:human genes:l:lipe|LIPE]]|0.409|
|[[:human genes:n:nbpf10|NBPF10]]|0.408|
|[[:human genes:s:s1pr4|S1PR4]]|0.408|
|[[:human genes:r:rpl10a|RPL10A]]|0.408|
|[[:human genes:p:psmd11|PSMD11]]|0.407|
|[[:human genes:t:traip|TRAIP]]|0.407|
|[[:human genes:u:ubap1|UBAP1]]|0.407|
|[[:human genes:c:ccdc94|CCDC94]]|0.407|
|[[:human genes:p:psmc5|PSMC5]]|0.407|
|[[:human genes:s:slc22a6|SLC22A6]]|0.407|
|[[:human genes:z:znf106|ZNF106]]|0.407|
|[[:human genes:s:sart1|SART1]]|0.407|
|[[:human genes:s:smg7|SMG7]]|0.406|
|[[:human genes:v:vps52|VPS52]]|0.406|
|[[:human genes:e:exosc8|EXOSC8]]|0.405|
|[[:human genes:s:strn|STRN]]|0.405|
|[[:human genes:m:myt1l|MYT1L]]|0.405|
|[[:human genes:s:sf3a3|SF3A3]]|0.405|
|[[:human genes:l:lad1|LAD1]]|0.405|
|[[:human genes:s:sap30bp|SAP30BP]]|0.405|
|[[:human genes:p:pbxip1|PBXIP1]]|0.405|
|[[:human genes:p:polr2a|POLR2A]]|0.404|
|[[:human genes:g:gnb3|GNB3]]|0.404|
|[[:human genes:t:tonsl|TONSL]]|0.404|
|[[:human genes:c:chst3|CHST3]]|0.404|
|[[:human genes:p:pcf11|PCF11]]|0.404|
|[[:human genes:r:rpl6|RPL6]]|0.404|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.403|
|[[:human genes:f:fbxw9|FBXW9]]|0.403|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.402|
|[[:human genes:m:myb|MYB]]|0.401|
|[[:human genes:a:adra1d|ADRA1D]]|0.401|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.4|
|[[:human genes:u:ubl5|UBL5]]|0.4|
|[[:human genes:r:rpl14|RPL14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2034
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC4A1 Expression in NALM6 Cells: 2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>