SLC4A7 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC4A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC4A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 4 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9497|9497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6M7|Q9Y6M7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC4A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC4A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 3 cyto|
|HCO3 cotransp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sodium:bicarbonate symporter activity|
|inorganic anion exchanger activity|
|auditory receptor cell development|
|inner ear auditory receptor cell differentiation|
|stereocilium|
|hair cell differentiation|
|inner ear receptor cell development|
|bicarbonate transport|
|neuroepithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|regulation of intracellular pH|
|regulation of cellular pH|
|columnar/cuboidal epithelial cell differentiation|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|sodium ion transport|
|inorganic anion transport|
|epithelial cell development|
|inner ear development|
|basolateral plasma membrane|
|ear development|
|cytoplasmic vesicle|
|synapse|
|anion transmembrane transport|
|epidermal cell differentiation|
|apical plasma membrane|
|monovalent inorganic cation transport|
|epidermis development|
|organic anion transport|
|sensory organ development|
|anion transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|epithelial cell differentiation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|neuron differentiation|
|chemical homeostasis|
|epithelium development|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.48|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.36|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.33|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.25|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-2.17|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.09|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.02|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.96|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.88|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.86|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.85|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.83|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.77|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.77|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.77|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.76|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.74|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.74|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.79|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.84|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.85|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.97|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.99|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.99|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.12|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.34|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.48|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.49|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.49|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.55|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.62|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.74|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.78|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.94|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.96|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.15|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|3.25|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.39|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|4.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ahcyl1|AHCYL1]]|0.675|
|[[:human genes:m:mapkapk5|MAPKAPK5]]|0.618|
|[[:human genes:m:mapk6|MAPK6]]|0.563|
|[[:human genes:d:dohh|DOHH]]|0.437|
|[[:human genes:v:vdac2|VDAC2]]|0.417|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.412|
|[[:human genes:z:znf592|ZNF592]]|0.412|
|[[:human genes:e:elf2|ELF2]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1820
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC4A7 Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>