SLC5A12 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC5A12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC5A12
  * **<color #00a2e8>Official Name</color>**: solute carrier family 5 member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=159963|159963]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q1EHB4|Q1EHB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC5A12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC5A12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612455|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). {ECO:0000250, ECO:0000269|PubMed:17692818}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SSF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|organic acid:sodium symporter activity|
|lactate transmembrane transporter activity|
|lactate transport|
|lactate transmembrane transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|sodium ion transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|apical plasma membrane|
|monovalent inorganic cation transport|
|organic anion transport|
|anion transport|
|metal ion transport|
|cation transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.09|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.07|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.89|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.77|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC5A12 Expression in NALM6 Cells: 2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>