SLC6A17 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC6A17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A17
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388662|388662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1V8|Q9H1V8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610299|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the SLC6 family of transporters, which are responsible for the presynaptic uptake of most neurotransmitters. The encoded vesicular transporter is selective for proline, glycine, leucine and alanine. In mouse, the strongest expression of this gene was in cortical and hippocampal tissues where expression increased during embryonic brain development and peaked postnatally. Defects in this gene cause a form of autosomal recessive intellectual disability. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO:0000250|UniProtKB:P31662}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leucine transport|
|branched-chain amino acid transport|
|proline transport|
|glycine transport|
|alanine transport|
|neurotransmitter:sodium symporter activity|
|integral component of synaptic vesicle membrane|
|neutral amino acid transport|
|L-amino acid transport|
|GABA-ergic synapse|
|amino acid transport|
|synaptic vesicle|
|drug transport|
|neurotransmitter transport|
|organic acid transport|
|carboxylic acid transport|
|glutamatergic synapse|
|organic anion transport|
|cell junction|
|anion transport|
|brain development|
|head development|
|cation transport|
|central nervous system development|
|response to drug|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.25|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.72|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.77|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.78|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.87|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.93|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.95|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.01|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.584|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.57|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.547|
|[[:human genes:c:chd4|CHD4]]|0.541|
|[[:human genes:d:ddtl|DDTL]]|0.53|
|[[:human genes:c:copg1|COPG1]]|0.53|
|[[:human genes:p:psmd14|PSMD14]]|0.528|
|[[:human genes:n:nup160|NUP160]]|0.527|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.525|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.516|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.515|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.515|
|[[:human genes:n:npipb5|NPIPB5]]|0.513|
|[[:human genes:c:ccna2|CCNA2]]|0.511|
|[[:human genes:p:pan2|PAN2]]|0.506|
|[[:human genes:n:nol10|NOL10]]|0.502|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.499|
|[[:human genes:r:rrp7a|RRP7A]]|0.498|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.498|
|[[:human genes:u:upf1|UPF1]]|0.498|
|[[:human genes:p:psma6|PSMA6]]|0.495|
|[[:human genes:p:psmb2|PSMB2]]|0.494|
|[[:human genes:t:twistnb|TWISTNB]]|0.488|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.488|
|[[:human genes:g:golga8o|GOLGA8O]]|0.486|
|[[:human genes:r:rps12|RPS12]]|0.485|
|[[:human genes:z:znf541|ZNF541]]|0.484|
|[[:human genes:p:psmd2|PSMD2]]|0.483|
|[[:human genes:p:polr2a|POLR2A]]|0.482|
|[[:human genes:e:egr2|EGR2]]|0.481|
|[[:human genes:z:zfand5|ZFAND5]]|0.478|
|[[:human genes:v:vasn|VASN]]|0.478|
|[[:human genes:r:rnf113a|RNF113A]]|0.477|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.476|
|[[:human genes:l:lrr1|LRR1]]|0.475|
|[[:human genes:t:ticrr|TICRR]]|0.475|
|[[:human genes:p:pola1|POLA1]]|0.475|
|[[:human genes:c:ctage4|CTAGE4]]|0.474|
|[[:human genes:p:psma7|PSMA7]]|0.474|
|[[:human genes:a:arcn1|ARCN1]]|0.474|
|[[:human genes:r:rpl35|RPL35]]|0.471|
|[[:human genes:i:ik|IK]]|0.471|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.471|
|[[:human genes:r:rnpc3|RNPC3]]|0.47|
|[[:human genes:d:dtl|DTL]]|0.47|
|[[:human genes:c:c14orf93|C14orf93]]|0.469|
|[[:human genes:s:sec13|SEC13]]|0.468|
|[[:human genes:c:copb2|COPB2]]|0.468|
|[[:human genes:n:nop16|NOP16]]|0.467|
|[[:human genes:t:timeless|TIMELESS]]|0.466|
|[[:human genes:c:cbwd3|CBWD3]]|0.466|
|[[:human genes:a:aamp|AAMP]]|0.465|
|[[:human genes:s:sart1|SART1]]|0.464|
|[[:human genes:s:supt5h|SUPT5H]]|0.464|
|[[:human genes:a:aatf|AATF]]|0.463|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.463|
|[[:human genes:n:napa|NAPA]]|0.462|
|[[:human genes:i:isy1|ISY1]]|0.462|
|[[:human genes:m:mcoln1|MCOLN1]]|0.462|
|[[:human genes:a:atxn1|ATXN1]]|0.462|
|[[:human genes:s:slc4a1|SLC4A1]]|0.462|
|[[:human genes:c:chmp4b|CHMP4B]]|0.461|
|[[:human genes:t:tspy8|TSPY8]]|0.46|
|[[:human genes:p:psmb4|PSMB4]]|0.459|
|[[:human genes:s:supt6h|SUPT6H]]|0.459|
|[[:human genes:r:rpl6|RPL6]]|0.459|
|[[:human genes:c:chaf1a|CHAF1A]]|0.458|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.458|
|[[:human genes:p:polr2d|POLR2D]]|0.458|
|[[:human genes:c:copb1|COPB1]]|0.457|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.457|
|[[:human genes:d:dhx38|DHX38]]|0.455|
|[[:human genes:d:dock6|DOCK6]]|0.454|
|[[:human genes:a:aqr|AQR]]|0.454|
|[[:human genes:u:utp3|UTP3]]|0.453|
|[[:human genes:d:ddx56|DDX56]]|0.452|
|[[:human genes:o:orc6|ORC6]]|0.452|
|[[:human genes:d:ddt|DDT]]|0.451|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.451|
|[[:human genes:r:rad51|RAD51]]|0.45|
|[[:human genes:m:mfrp|MFRP]]|0.45|
|[[:human genes:p:pwp2|PWP2]]|0.449|
|[[:human genes:s:setd1a|SETD1A]]|0.449|
|[[:human genes:r:rfc1|RFC1]]|0.449|
|[[:human genes:c:col2a1|COL2A1]]|0.449|
|[[:human genes:c:ccdc116|CCDC116]]|0.448|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.446|
|[[:human genes:p:plxnb3|PLXNB3]]|0.446|
|[[:human genes:f:fam160a1|FAM160A1]]|0.445|
|[[:human genes:t:taf1|TAF1]]|0.445|
|[[:human genes:f:fcn2|FCN2]]|0.444|
|[[:human genes:n:nup153|NUP153]]|0.444|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.444|
|[[:human genes:s:smtn|SMTN]]|0.444|
|[[:human genes:s:slc38a7|SLC38A7]]|0.443|
|[[:human genes:h:hap1|HAP1]]|0.443|
|[[:human genes:m:mfsd12|MFSD12]]|0.443|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.443|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.442|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.442|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.442|
|[[:human genes:c:copa|COPA]]|0.442|
|[[:human genes:r:rps2|RPS2]]|0.442|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.442|
|[[:human genes:i:igfn1|IGFN1]]|0.442|
|[[:human genes:f:fam25b|FAM25B]]|0.442|
|[[:human genes:p:polr2h|POLR2H]]|0.442|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.44|
|[[:human genes:m:mbtd1|MBTD1]]|0.44|
|[[:human genes:p:pola2|POLA2]]|0.439|
|[[:human genes:e:eif4a3|EIF4A3]]|0.439|
|[[:human genes:k:kctd17|KCTD17]]|0.437|
|[[:human genes:k:krt78|KRT78]]|0.437|
|[[:human genes:n:nupl1|NUPL1]]|0.436|
|[[:human genes:z:znf830|ZNF830]]|0.436|
|[[:human genes:s:sult1a3|SULT1A3]]|0.436|
|[[:human genes:n:nbpf10|NBPF10]]|0.436|
|[[:human genes:s:snx15|SNX15]]|0.436|
|[[:human genes:s:snip1|SNIP1]]|0.435|
|[[:human genes:s:sult1a4|SULT1A4]]|0.435|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.434|
|[[:human genes:h:hivep3|HIVEP3]]|0.434|
|[[:human genes:p:psmc2|PSMC2]]|0.434|
|[[:human genes:v:vps52|VPS52]]|0.434|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.433|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.432|
|[[:human genes:m:myt1l|MYT1L]]|0.431|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.431|
|[[:human genes:p:pole|POLE]]|0.431|
|[[:human genes:k:krt2|KRT2]]|0.429|
|[[:human genes:a:ankle2|ANKLE2]]|0.429|
|[[:human genes:c:crnkl1|CRNKL1]]|0.429|
|[[:human genes:r:rbm39|RBM39]]|0.428|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.428|
|[[:human genes:l:lad1|LAD1]]|0.428|
|[[:human genes:o:osbp|OSBP]]|0.427|
|[[:human genes:p:pan3|PAN3]]|0.427|
|[[:human genes:e:exosc6|EXOSC6]]|0.426|
|[[:human genes:n:nup205|NUP205]]|0.425|
|[[:human genes:e:exosc5|EXOSC5]]|0.425|
|[[:human genes:a:akirin2|AKIRIN2]]|0.424|
|[[:human genes:o:ogfr|OGFR]]|0.424|
|[[:human genes:s:sf3a3|SF3A3]]|0.424|
|[[:human genes:s:smg1|SMG1]]|0.424|
|[[:human genes:p:pigs|PIGS]]|0.423|
|[[:human genes:s:slc5a5|SLC5A5]]|0.422|
|[[:human genes:w:wdr75|WDR75]]|0.422|
|[[:human genes:s:sema6b|SEMA6B]]|0.422|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.421|
|[[:human genes:r:rpp40|RPP40]]|0.421|
|[[:human genes:m:med15|MED15]]|0.421|
|[[:human genes:r:rbm48|RBM48]]|0.421|
|[[:human genes:t:tsg101|TSG101]]|0.421|
|[[:human genes:m:med14|MED14]]|0.421|
|[[:human genes:r:rffl|RFFL]]|0.42|
|[[:human genes:a:ankle1|ANKLE1]]|0.42|
|[[:human genes:c:cbwd5|CBWD5]]|0.42|
|[[:human genes:r:rrm2|RRM2]]|0.42|
|[[:human genes:r:rrp15|RRP15]]|0.42|
|[[:human genes:p:psmd3|PSMD3]]|0.419|
|[[:human genes:h:hinfp|HINFP]]|0.419|
|[[:human genes:p:pbxip1|PBXIP1]]|0.419|
|[[:human genes:p:psmb3|PSMB3]]|0.419|
|[[:human genes:p:ppp1r10|PPP1R10]]|0.418|
|[[:human genes:c:cep192|CEP192]]|0.418|
|[[:human genes:p:psmd11|PSMD11]]|0.417|
|[[:human genes:b:brd2|BRD2]]|0.415|
|[[:human genes:n:npipb8|NPIPB8]]|0.415|
|[[:human genes:p:psmc1|PSMC1]]|0.415|
|[[:human genes:r:rbbp5|RBBP5]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:e:exosc3|EXOSC3]]|0.414|
|[[:human genes:a:apc2|APC2]]|0.414|
|[[:human genes:e:exosc9|EXOSC9]]|0.412|
|[[:human genes:p:paf1|PAF1]]|0.412|
|[[:human genes:c:cdc6|CDC6]]|0.412|
|[[:human genes:c:cactin|CACTIN]]|0.412|
|[[:human genes:z:znf675|ZNF675]]|0.411|
|[[:human genes:m:mt1e|MT1E]]|0.411|
|[[:human genes:t:tyms|TYMS]]|0.411|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.411|
|[[:human genes:r:rangap1|RANGAP1]]|0.411|
|[[:human genes:p:polr2f|POLR2F]]|0.411|
|[[:human genes:t:tpx2|TPX2]]|0.411|
|[[:human genes:n:nol7|NOL7]]|0.41|
|[[:human genes:r:rps3a|RPS3A]]|0.41|
|[[:human genes:n:ncapg|NCAPG]]|0.41|
|[[:human genes:c:cbwd6|CBWD6]]|0.41|
|[[:human genes:n:nup133|NUP133]]|0.41|
|[[:human genes:g:golga6a|GOLGA6A]]|0.409|
|[[:human genes:c:cdc45|CDC45]]|0.409|
|[[:human genes:w:wapal|WAPAL]]|0.407|
|[[:human genes:c:casc3|CASC3]]|0.407|
|[[:human genes:n:nup85|NUP85]]|0.407|
|[[:human genes:m:myo1h|MYO1H]]|0.407|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.406|
|[[:human genes:t:tagln|TAGLN]]|0.406|
|[[:human genes:m:mylk3|MYLK3]]|0.406|
|[[:human genes:r:rpl30|RPL30]]|0.406|
|[[:human genes:c:cln6|CLN6]]|0.405|
|[[:human genes:i:ints5|INTS5]]|0.405|
|[[:human genes:b:bysl|BYSL]]|0.405|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.405|
|[[:human genes:s:sap30bp|SAP30BP]]|0.405|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.404|
|[[:human genes:c:cope|COPE]]|0.404|
|[[:human genes:c:copz1|COPZ1]]|0.404|
|[[:human genes:n:nol12|NOL12]]|0.403|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.403|
|[[:human genes:r:rad21|RAD21]]|0.403|
|[[:human genes:p:psmd6|PSMD6]]|0.403|
|[[:human genes:f:fam231a|FAM231A]]|0.402|
|[[:human genes:f:fam231c|FAM231C]]|0.402|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.401|
|[[:human genes:m:myh7b|MYH7B]]|0.401|
|[[:human genes:d:disp2|DISP2]]|0.4|
|[[:human genes:c:cgb2|CGB2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A17 Expression in NALM6 Cells: -0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>