SLC6A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC6A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6529|6529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30531|P30531]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-aminobutyric acid import|
|positive regulation of gamma-aminobutyric acid secretion|
|gamma-aminobutyric acid:sodium symporter activity|
|response to disaccharide|
|regulation of gamma-aminobutyric acid secretion|
|negative regulation of synaptic transmission, GABAergic|
|response to sucrose|
|neurotransmitter binding|
|gamma-aminobutyric acid transport|
|neurotransmitter reuptake|
|positive regulation of amino acid transport|
|amino acid import|
|response to lead ion|
|neurotransmitter uptake|
|regulation of amino acid transport|
|regulation of synaptic transmission, GABAergic|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|integral component of postsynaptic membrane|
|acidic amino acid transport|
|positive regulation of anion transport|
|response to cocaine|
|regulation of organic acid transport|
|integral component of presynaptic membrane|
|negative regulation of synaptic transmission|
|GABA-ergic synapse|
|response to anesthetic|
|regulation of amine transport|
|regulation of anion transport|
|response to alkaloid|
|amino acid transport|
|response to estradiol|
|monocarboxylic acid transport|
|regulation of neurotransmitter transport|
|learning|
|response to calcium ion|
|response to purine-containing compound|
|response to carbohydrate|
|neurotransmitter transport|
|response to ammonium ion|
|learning or memory|
|positive regulation of ion transport|
|carboxylic acid transport|
|organic acid transport|
|axon|
|cognition|
|response to xenobiotic stimulus|
|neuron projection|
|protein homooligomerization|
|regulation of neurotransmitter levels|
|response to metal ion|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|response to toxic substance|
|protein complex oligomerization|
|response to inorganic substance|
|behavior|
|anion transport|
|cell surface|
|import into cell|
|regulation of ion transport|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|cell-cell signaling|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A1 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>