SLC6A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC6A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6531|6531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01959|Q01959]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126455|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO:0000269|PubMed:1406597, ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:8302271}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dopamine:sodium symporter activity|
|monoamine transmembrane transporter activity|
|dopamine catabolic process|
|catecholamine uptake|
|flotillin complex|
|dopamine uptake|
|catechol-containing compound catabolic process|
|catecholamine catabolic process|
|dopamine biosynthetic process|
|dopamine transport|
|phenol-containing compound catabolic process|
|neurotransmitter:sodium symporter activity|
|dopamine binding|
|adenohypophysis development|
|dopaminergic synapse|
|catecholamine transport|
|prepulse inhibition|
|catechol-containing compound biosynthetic process|
|catecholamine biosynthetic process|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|monoamine transport|
|startle response|
|neurotransmitter uptake|
|dopamine metabolic process|
|positive regulation of multicellular organism growth|
|protein phosphatase 2A binding|
|response to iron ion|
|phenol-containing compound biosynthetic process|
|pituitary gland development|
|neurotransmitter biosynthetic process|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|lactation|
|integral component of postsynaptic membrane|
|response to nicotine|
|ammonium transport|
|response to cocaine|
|integral component of presynaptic membrane|
|regulation of multicellular organism growth|
|body fluid secretion|
|organic hydroxy compound catabolic process|
|diencephalon development|
|response to anesthetic|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|response to cAMP|
|protease binding|
|protein N-terminus binding|
|neuromuscular process|
|response to alkaloid|
|endocrine system development|
|response to ethanol|
|mammary gland development|
|response to organophosphorus|
|organic hydroxy compound transport|
|drug catabolic process|
|drug transport|
|response to purine-containing compound|
|positive regulation of developmental growth|
|neurotransmitter transport|
|response to ammonium ion|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|locomotory behavior|
|membrane raft|
|response to alcohol|
|positive regulation of growth|
|protein-containing complex binding|
|aging|
|axon|
|response to xenobiotic stimulus|
|response to antibiotic|
|neuron projection|
|regulation of developmental growth|
|signaling receptor binding|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|response to metal ion|
|neuronal cell body|
|forebrain development|
|gland development|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|sensory perception of smell|
|organic cyclic compound catabolic process|
|regulation of body fluid levels|
|drug metabolic process|
|response to toxic substance|
|response to inorganic substance|
|sensory perception of chemical stimulus|
|behavior|
|cell surface|
|regulation of growth|
|import into cell|
|brain development|
|head development|
|cation transport|
|response to organic cyclic compound|
|sensory perception|
|central nervous system development|
|response to organonitrogen compound|
|response to drug|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|secretion|
|aromatic compound biosynthetic process|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8630
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A3 Expression in NALM6 Cells: -0.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>