SLC6A8 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC6A8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A8
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6535|6535]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48029|P48029]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the uptake of creatine in muscles and brain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|creatine:sodium symporter activity|
|creatine transmembrane transporter activity|
|creatine transmembrane transport|
|choline transmembrane transporter activity|
|creatine metabolic process|
|choline transport|
|neurotransmitter:sodium symporter activity|
|modified amino acid transport|
|organic cation transport|
|ammonium transport|
|drug transmembrane transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|monocarboxylic acid transport|
|drug transport|
|sodium ion transport|
|neurotransmitter transport|
|cellular modified amino acid metabolic process|
|muscle contraction|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|muscle system process|
|monovalent inorganic cation transport|
|organic anion transport|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|anion transport|
|metal ion transport|
|molecular function|
|cation transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|small molecule metabolic process|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11582
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A8 Expression in NALM6 Cells: -0.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>