SLC7A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC7A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6541|6541]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30825|P30825]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. {ECO:0000269|PubMed:10485994}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-arginine import across plasma membrane|
|arginine transmembrane transporter activity|
|L-lysine transmembrane transporter activity|
|L-ornithine transmembrane transporter activity|
|L-arginine transmembrane transport|
|L-lysine transmembrane transport|
|L-lysine transport|
|arginine transmembrane transport|
|L-arginine transport|
|L-ornithine transmembrane transport|
|ornithine transport|
|arginine transport|
|basic amino acid transmembrane transport|
|basic amino acid transport|
|amino acid import across plasma membrane|
|amino acid import|
|amino acid transmembrane transporter activity|
|L-alpha-amino acid transmembrane transport|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|import across plasma membrane|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|organic anion transport|
|anion transport|
|protein-containing complex|
|cation transmembrane transport|
|import into cell|
|cation transport|
|ion transmembrane transport|
|response to drug|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.86|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.73|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.75|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.75|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.77|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.83|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.85|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.87|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.92|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.93|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.98|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.98|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.03|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.06|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.07|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.08|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.13|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.17|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.18|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.22|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.24|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.26|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.26|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.29|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.29|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.31|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.32|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.41|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.42|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.44|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.45|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.46|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.5|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.53|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.63|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.64|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.72|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.81|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.89|
|[[:results:exp274|Citral 50μM R06 exp274]]|3.08|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.41|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|4.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kti12|KTI12]]|0.455|
|[[:human genes:c:ctu2|CTU2]]|0.453|
|[[:human genes:u:urm1|URM1]]|0.453|
|[[:human genes:c:ctu1|CTU1]]|0.449|
|[[:human genes:m:mocs3|MOCS3]]|0.439|
|[[:human genes:e:elp3|ELP3]]|0.43|
|[[:human genes:n:nars2|NARS2]]|0.427|
|[[:human genes:p:pmvk|PMVK]]|0.425|
|[[:human genes:d:dnlz|DNLZ]]|0.424|
|[[:human genes:e:elp6|ELP6]]|0.42|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.418|
|[[:human genes:t:trmt61a|TRMT61A]]|0.405|
|[[:human genes:d:dph5|DPH5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 524
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A1 Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>