SLC7A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC7A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6542|6542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52569|P52569]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601872|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:9174363}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nitric oxide production involved in inflammatory response|
|L-arginine transmembrane transporter activity|
|L-arginine import across plasma membrane|
|L-lysine transmembrane transporter activity|
|arginine transmembrane transporter activity|
|L-ornithine transmembrane transporter activity|
|L-arginine transmembrane transport|
|L-lysine transmembrane transport|
|L-lysine transport|
|arginine transmembrane transport|
|L-ornithine transmembrane transport|
|L-arginine transport|
|basic amino acid transmembrane transporter activity|
|ornithine transport|
|arginine transport|
|basic amino acid transmembrane transport|
|nitric oxide biosynthetic process|
|basic amino acid transport|
|amino acid import across plasma membrane|
|production of molecular mediator involved in inflammatory response|
|nitric oxide metabolic process|
|reactive nitrogen species metabolic process|
|amino acid import|
|reactive oxygen species biosynthetic process|
|amino acid transmembrane transporter activity|
|neurotransmitter biosynthetic process|
|L-alpha-amino acid transmembrane transport|
|macrophage activation|
|regulation of macrophage activation|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|neurotransmitter metabolic process|
|import across plasma membrane|
|reactive oxygen species metabolic process|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|drug transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cellular amino acid metabolic process|
|regulation of inflammatory response|
|regulation of neurotransmitter levels|
|organic anion transport|
|inflammatory response|
|drug metabolic process|
|cell junction|
|anion transport|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|cation transmembrane transport|
|regulation of cell activation|
|import into cell|
|regulation of defense response|
|cation transport|
|carboxylic acid metabolic process|
|leukocyte activation|
|ion transmembrane transport|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|cell activation|
|regulation of response to external stimulus|
|transmembrane transport|
|defense response|
|ion transport|
|integral component of plasma membrane|
|regulation of response to stress|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|small molecule metabolic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A2 Expression in NALM6 Cells: 0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>