SLC7A6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC7A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9057|9057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92536|Q92536]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605641|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-amino acid transmembrane transporter activity|
|antiporter activity|
|amino acid transmembrane transporter activity|
|L-alpha-amino acid transmembrane transport|
|L-amino acid transport|
|amino acid transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|basolateral plasma membrane|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cellular amino acid metabolic process|
|leukocyte migration|
|organic anion transport|
|anion transport|
|intracellular membrane-bounded organelle|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cell migration|
|oxoacid metabolic process|
|organic acid metabolic process|
|cell motility|
|localization of cell|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|small molecule metabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-5.33|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-3.31|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-3.29|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-3.06|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.33|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.83|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.81|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A6 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>